Title:
【発明の名称】イミダゾ[1,5-a]インドール-3-オンのアザビシクロアルキル誘導体およびそれらの製造法
Document Type and Number:
Japanese Patent JPH09500913
Kind Code:
A
Abstract:
PCT No. PCT/EP95/01652 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed May 2, 1995 PCT Pub. No. WO95/32209 PCT Pub. Date Nov. 30, 1995Novel 5-HT3 receptor antagonist compounds having the general formula (I) (I) wherein each of R, R1 and R2, which may be the same or different, is hydrogen, halogen, hydroxy, cyano, C1-C6 alkyl, CF3, C1-C6 alkoxy, C1-C6 alkylthio, formyl, C2-C6 alkanoyl, carboxy, C1-C6 alkoxy-carbonyl, nitro, -N(R4 R5) in which each of R4 and R5 independently is hydrogen, C1-C6 alkyl, formyl or C2-C6 alkanoyl; or a (R6 R7)N-SO2 group, in which each of R6 and R7 independently is hydrogen or C1-C6 alkyl; R3 is a group a) or b) wherein n is an integer of 1 or 2 and R8 is hydrogen, C1-C6 alkyl unsubstituted or substituted by phenyl, C2-C4 alkenyl, C2-C4 alkynyl, formyl or C2-C6 alkanoyl; and the pharmaceutically acceptable salts thereof, are provided.
Inventors:
Baracy, Mario
Heidenperger, Franco
Kathia, Carla
Salvation, Patricia
Heidenperger, Franco
Kathia, Carla
Salvation, Patricia
Application Number:
JP53001095A
Publication Date:
January 28, 1997
Filing Date:
May 02, 1995
Export Citation:
Assignee:
Falmatia Esset Pear
International Classes:
A61K31/41; A61K31/435; A61K31/439; A61K31/46; A61P1/00; A61P1/08; A61P25/00; A61P25/06; A61P25/18; A61P25/22; A61P25/28; A61P25/36; A61P43/00; C07D451/04; C07D451/14; C07D453/02; C07D519/00; (IPC1-7): C07D519/00; A61K31/41; A61K31/435; C07D451/04; C07D453/02
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)