Title:
【発明の名称】患者におけるアルツハイマー病診断用の非侵入的方法
Document Type and Number:
Japanese Patent JPH10503209
Kind Code:
A
Abstract:
The present invention provides non-invasive methods for diagnosing Alzheimer's disease in a living human subject. One method employs a non-invasive automated apparatus which can continuously monitor pupil diameter size over time; repetitively measure pupil diameter size over time for a pre-chosen duration ranging from about less than 1 second to about 5 minutes; and cumulatively record size information as it is obtained over time. A second method employs an apparatus which can repetitively measure pupil constriction velocity for a pre-chosen duration both before and after stimulation by visible light. Both methods require the administration of at least one neural transmitter mediator to a targeted eye of the living subject in an amount insufficient to cause marked changes in pupil diameter size over time in a person who is not afflicted with Alzheimer's disease. The marked hypersensitivity of an Alzheimer's dementia patient to the administered neural transmitter mediator serves as the means for identifying individuals afflicted with Alzheimer's disease.
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Inventors:
Sint, Leonard
Duffner, Kirk Earl
Duffner, Kirk Earl
Application Number:
JP50594096A
Publication Date:
March 24, 1998
Filing Date:
July 24, 1995
Export Citation:
Assignee:
Beth Israel Hospital Association
International Classes:
A61B3/11; A61B5/16; A61K49/00; (IPC1-7): A61K49/00; A61B3/11
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)