Title:
【発明の名称】新しいプロテインキナーゼ(NPK-110)
Document Type and Number:
Japanese Patent JPH10508199
Kind Code:
A
Abstract:
The present invention relates to a DNA sequence encoding a novel neuronal protein kinase (NPK) which phosphorylates tau proteins as well as other microtubule associated proteins (MAPs) in positions crucial for the binding to microtubules. The invention further relates to Serine or Theorine residues and epitopes comprising said residues phosphorylated by said NPK on said MAPs, to antibodies specifically binding to said protein kinase, pharmaceutical compositions comprising inhibitors to said protein kinase, in particular for the treatment of Alzheimer's disease and cancer, to diagnostic kits and to in vitro diagnostic methods for the detection of Alzheimer's disease and cancer.
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Inventors:
Mandelkow, Eckhart
Mandelkow, Eva-Maria
Bier nut, jasec
Drews, gerald
Mandelkow, Eva-Maria
Bier nut, jasec
Drews, gerald
Application Number:
JP51432396A
Publication Date:
August 18, 1998
Filing Date:
October 30, 1995
Export Citation:
Assignee:
Max-Plank-Gezelle Shaft Tool Felderung del Wissen Schaften A. We.
International Classes:
C12N15/09; A61K38/00; A61K38/16; A61K38/43; A61K38/46; A61K39/395; A61P25/28; A61P35/00; C07C229/08; C07K1/14; C07K4/12; C07K14/47; C07K16/40; C12N1/21; C12N9/12; C12N15/54; C12P21/08; C12Q1/42; C12Q1/48; C12R1/19; (IPC1-7): C12N15/09; A61K38/00; A61K38/43; A61K39/395; C07K1/14; C07K14/47; C07K16/40; C12N1/21; C12N9/12; C12P21/08; C12Q1/42; C12Q1/48
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)