Title:
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
Document Type and Number:
Japanese Patent JPWO2015108048
Kind Code:
A1
Abstract:
【解決課題】 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤を提供する。【解決手段】 ５’−Ｘ１ＣｐＧＸ２−３’からなる配列であるＣｐＧモチーフを２〜４個含む１４〜３２ヌクレオチド長のオリゴヌクレオチドを含むアジュバンドであって，少なくとも２つのＣｐＧモチーフの３’側にホスホロチオエート（ＰＳ）結合された核酸塩基が接続され，５’末端及び３’末端は，ＰＳ結合されたＳ型の核酸塩基であり，前記オリゴヌクレオチドは，ＰＳ修飾されていない塩基を少なくともひとつ以上含むアジュバンド。そのアジュバンドを含む抗腫瘍剤。【選択図】 図１
Inventors:
Genban Takeru
Ryoichi Nagata
Yusuke Torikai
Ryoichi Nagata
Yusuke Torikai
Application Number:
JP2015557839A
Publication Date:
March 23, 2017
Filing Date:
January 14, 2015
Export Citation:
Assignee:
Shin Nihon Kagaku Co., Ltd.
Wave life sciences japan Co., Ltd.
Wave life sciences japan Co., Ltd.
International Classes:
A61K39/39; A61K31/7125; A61K48/00; A61P35/00; A61P43/00; C12N15/117
Domestic Patent References:
| JP2008501787A | 2008-01-24 | |||
| JP2008502713A | 2008-01-31 | |||
| JP2009528027A | 2009-08-06 | |||
| JP2001503267A | 2001-03-13 | |||
| JP2003510290A | 2003-03-18 | |||
| JPH10506265A | 1998-06-23 | |||
| JP2002521489A | 2002-07-16 | |||
| JP2015557837A | ||||
| JP2015557838A |
Other References:
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KAUR, H. ET AL.: "Activation of natural killer-like YT-INDY cells by oligodeoxynucleotides and binding by homologous p", SCANDINAVIAN JOURNAL OF IMMUNOLOGY, vol. 62, JPN6015014828, 2005, pages 361 - 370, XP055213368, ISSN: 0003858537, DOI: 10.1111/j.1365-3083.2005.01665.x
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HARTMANN, G. ET AL.: "Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for activating primate immune responses i", THE JOURNAL OF IMMUNOLOGY, vol. 164, no. 3, JPN6015014833, 2000, pages 1617 - 1624, XP002647151, ISSN: 0003858539
HARTMANN, B. ET AL.: "Sequence effects on energetic and structural properties of phosphorothioate DNA: a molecular modelli", NUCLEIC ACID RESEARCH, vol. 27, no. 16, JPN7015000999, 1999, pages 3342 - 3347, XP055213443, ISSN: 0003858540, DOI: 10.1093/nar/27.16.3342
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BARTZ, H. ET AL.: "Poly-guanosine strings improve cellular uptake and stimulatory activity of phosphodiester CpG oligon", VACCINE, vol. 23, JPN6015014822, 2004, pages 148 - 155, XP004627837, ISSN: 0003858534, DOI: 10.1016/j.vaccine.2004.05.020
"がん治療用ワクチン・アジュバント非臨床試験ガイダンス", がん免疫療法開発のガイダンス 2016[ONLINE],RETRIEVED ON 2020 FEB 27, JPN6020008406, 26 December 2016 (2016-12-26), pages 4 - 6, ISSN: 0004226295
Attorney, Agent or Firm:
Takayuki Hirose
Daisuke Seki
Daisuke Seki
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