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Title:
殺細胞効果を有するキメラ抗原受容体遺伝子改変リンパ球
Document Type and Number:
Japanese Patent JPWO2018110374
Kind Code:
A1
Abstract:
本発明は、CAR療法の臨床応用を更に進めるべく、固形腫瘍領域での治療戦略及びそのために有用な手段の提供を課題とする。EphrinB2細胞外ドメインを抗原認識部位にもつキメラ抗原受容体を発現する遺伝子改変リンパ球を作製する。

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Inventors:
Hosoi Hajime
Tomoko Iehara
Shigeki Yagyu
Nakazawa Yozo
Application Number:
JP2018556602A
Publication Date:
October 24, 2019
Filing Date:
December 06, 2017
Export Citation:
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Assignee:
Shinshu University
Kyoto Prefectural University Corporation
International Classes:
C12N15/62; C07K14/705; C07K19/00; C12N5/0783; C12N5/10; C12N15/63
Domestic Patent References:
JP2013536806A2013-09-26
JP2011256179A2011-12-22
JP2008545375A2008-12-18
JP2013189443A2013-09-26
Other References:
中川岳志, 外２名: "キメラ抗原受容体（ＣＡＲ）発現細胞傷害性Ｔ細胞（ＣＴＬ）を用いた次世代養子免疫療法の開発", DRUG DELIVERY SYSTEM (2013) VOL.28-1, PP.35-44, JPN6018005831, ISSN: 0004601049
中沢洋三: "キメラ抗原受容体（ＣＡＲ）を用いた遺伝子改変Ｔ細胞療法", 信州医誌 (2013) VOL.61, NO.4, PP.197-203, JPN6018005832, ISSN: 0004601050
CYTOTHERAPY (2014) VOL.16, PP.1257-1269, JPN6018005835, ISSN: 0004601051
EXPERIMENTAL AND MOLECULAR PATHOLOGY (2016) VOL.100, PP.402-408, JPN6018005836, ISSN: 0004601052
NATURE CELL BIOLOGY (2006) VOL.8, NO.8, PP.815-825, JPN6018005838, ISSN: 0004601053
Attorney, Agent or Firm:
Mikiharu Hagino



 
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