1-METHYLCARBAPENEMS HAVING 2-POSITION SUBSTITUENT BONDED WITH ALKYLENETHIO BRIDGE

Title:

1-METHYLCARBAPENEMS HAVING 2-POSITION SUBSTITUENT BONDED WITH ALKYLENETHIO BRIDGE

Document Type and Number:

Japanese Patent JPS61151192

Kind Code:

A

Abstract:

1-Methylcarbapenems having the formula: wherein: R<1> and R<2> are independently H, CH3-, CH3CH2-, (CH3)2CH-, HOCH2-, CH3CH(OH)-, (CH3)2C(OH)-, FCH2, F2CH-, F3C-, CH3CH(F)-, CH3CF2- or (CH3)2C(F)-; R<3> is CH3; R<4> is a bridging group comprising substituted or unsubstituted C1-C4 straight, C2-C6 branched or C3-C7 cycloalkyl groups wherein the substituents are selected from C1-C6 alkyl, O-C1-C6 alkyl, S-C1-C6 alkyl, CF3, N(C1-C6 alkyl)2; X is -S-, -@-, -SO2-, -O- or -NH; and R<5> is, e.g., C1-C10 straight or branched alkyl; their preparation and antibiotic use are disclosed.

Inventors:

TOOMASU ENU ZARUTSUMAN
BAATON JII KURISUTENSEN
JIEEMUSU BUI HETSUKU
DEIBUITSUDO ETSUCHI SHII

Application Number:

JP27938385A

Publication Date:

July 09, 1986

Filing Date:

December 13, 1985

Export Citation:

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Assignee:

MERCK & CO INC

International Classes:

C07D487/04; A61K31/40; A61P31/04; C07D477/14; C07F7/18; C07F9/568; (IPC1-7): A61K31/40; C07D487/04

Domestic Patent References:

JPS56122379A	1981-09-25
JPS57144285A	1982-09-06
JPS58103388A	1983-06-20
JPS5936677A	1984-02-28

Attorney, Agent or Firm:

Masao Okabe

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