Title:
CARBAPENEM AND 1-METHYLCARBAPENEMS HAVING 2-HETEROARYLIUM FATTY GROUP SUBSTITUENT
Document Type and Number:
Japanese Patent JPS61151191
Kind Code:
A
Abstract:
Carbapenems and 1-methylcarbapenems having the formula:wherein - R1 and R2 are independently H. CH3. CH3CH2-, (CH3)2CH-, HOCH2, CH3CH(OH)-, (CH3)2C(OH)-, FCH2-, F2CH, F3C-, CH3CH(F)-, CH3CF2-, or (CH3)2C(F)-; R3 is H-or CH3; L is a bridging group comprising substituted or unsubstituted C1-C6 straight. C2-C6 branched or C3-C7 cycloalkyl groups wherein the substituents are selected from C1-C6 alkyl, O-C1-C6 alkyl, S-C1-C6 alkyl, CF3, N(C1-C6 alkyl)2. is a quaternary, monocyclic or bicyclic substituted or unsubstituted, heteroaryl group containing (a) when monocyclic, up to 3 heteroatoms and up to 6 total ring atoms, or (b) when bicyclic, up to 5 heteroatoms and 9-10 ring atoms, which is optionally substituted with one or more groups; and Y is a carboxy-containing group; their preparation and antibiotic use are disclosed.
Inventors:
CHRISTENSEN BURTON G (US)
SALZMANN THOMAS N (US)
HECK JAMES V (US)
SALZMANN THOMAS N (US)
HECK JAMES V (US)
Application Number:
JP27938085A
Publication Date:
July 09, 1986
Filing Date:
December 13, 1985
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
C07D487/04; A61K31/397; A61K31/40; A61K31/44; A61P31/04; C07D477/00; C07D477/14; (IPC1-7): A61K31/40; B63B9/06; C07D487/04
Attorney, Agent or Firm:
Masao Okabe
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