Title:
11-ベータヒドロキシステロイド脱水素酵素阻害剤としてのアダマンチルアセトアミド
Document Type and Number:
Japanese Patent JP4919599
Kind Code:
B2
Abstract:
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R1 and R2 each independently represents hydrogen C1-4alkyl, NR9R10, C1-4alkyloxy; or R1 and R2 taken together with the carbon atom with which they are attached form a C3-6cycloalkyl; and where n is 2, either R1 or R2 may be absent to form an unsaturated bond; R3 represents a C6-12cycloalkyl, preferably selected from cylo-octanyl and cyclohexyl or R3 represents a monovalent radical having one of the following formulae wherein said C6-12cycloalkyl or monovalent radical may optionally be substituted with one, or where possible two, three or more substituents selected from the group consisting of C1-4alkyl, C1-4alkyloxy, halo or hydroxy; Q represents Het1 or Ar2 wherein said C3-8cycloalkyl, Het1 or Ar2 are optionally substituted with one or where possible two or more substituents selected from halo, C1-4alkyl, C1-4alkyloxy, hydroxy, nitro, NR5R6, C1-4alkyloxy substituted with one or where possible two, three or more substituents each independently selected from hydroxycarbonyl, Het2 and NR7R8, and C1-4alkyl substituted with one or where possible two or three halo substituents, preferably trifluoromethyl; R5 and R6 each independently represent hydrogen, C1-4alkyl, or C1-4alkyl substituted with phenyl; R7 and R8 each independently represent hydrogen or C1-4alkyl; R9 and R10 each independently represent hydrogen, C1-4alkyl or C1-4alkyloxycarbonyl; L represents C1-4alkyl; Het1 represents a heterocycle selected from pyridinyl, thiophenyl, or 1,3-benzodioxolyl; Het2 represents piperidinyl, pyrrolidinyl or morpholinyl; Ar2 represents phenyl, naphtyl or indenyl.
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Inventors:
Linders, Johannes Theodorus Maria
Willemsens, Gustav Henri Maria
Gironsen, Ronaldus Arnodous Hendrika Joseph
Buik, Christoph Francis Robert Nestor
Banhof, Greta Constantia Peter
Van der Beken, Luis Joseph Elisabeth
Yaroskova, Ribze
Willemsens, Gustav Henri Maria
Gironsen, Ronaldus Arnodous Hendrika Joseph
Buik, Christoph Francis Robert Nestor
Banhof, Greta Constantia Peter
Van der Beken, Luis Joseph Elisabeth
Yaroskova, Ribze
Application Number:
JP2004561497A
Publication Date:
April 18, 2012
Filing Date:
December 16, 2003
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07C233/08; A61K31/16; A61K31/165; A61K31/19; A61K31/192; A61K31/216; A61K31/27; A61K31/275; A61K31/335; A61K31/351; A61K31/353; A61K31/357; A61K31/381; A61K31/382; A61K31/40; A61K31/4015; A61K31/402; A61K31/404; A61K31/405; A61K31/41; A61K31/426; A61K31/44; A61K31/4406; A61K31/4409; A61K31/47; A61K31/472; A61K31/495; A61K31/551; A61P3/04; A61P3/10; A61P5/38; A61P5/46; A61P19/10; A61P25/28; A61P27/06; A61P43/00; C07C233/11; C07C233/14; C07C233/22; C07C233/23; C07C233/32; C07C233/41; C07C233/58; C07C235/36; C07C235/40; C07C237/20; C07C237/22; C07C255/41; C07C255/57; C07C271/22; C07D207/12; C07D207/27; C07D209/08; C07D209/18; C07D213/56; C07D215/08; C07D215/48; C07D217/06; C07D217/26; C07D243/08; C07D257/04; C07D277/40; C07D277/48; C07D295/08; C07D295/088; C07D295/092; C07D295/14; C07D295/155; C07D295/18; C07D295/185; C07D309/12; C07D311/58; C07D311/64; C07D317/60; C07D317/72; C07D333/24; C07D333/68; C07D335/06; C07D207/26
Domestic Patent References:
| JPS59175472A | 1984-10-04 | |||
| JP2001524468A | 2001-12-04 | |||
| JPH0386853A | 1991-04-11 | |||
| JPS59164779A | 1984-09-17 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office