Title:
１，４－ベンゾジアゼピン－２－オン誘導体およびその使用
Document Type and Number:
Japanese Patent JP7040819
Kind Code:
B2
Abstract:
Derivatives having the general formula (I) and being limited to structural variants. The claimed compounds are used in the field of medicine as analgesics, anorexigenic or orexigenic agents for regulating weight (loss or gain), antidepressants and anxiolytics for treating psychological disorders, and also antihypoxic and nootropic agents for the prophylaxis and treatment of central nervous system disorders.
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Inventors:
Pavlovsky Victor Ivanovich
Hazarnov Veniamine Abramovich
Stankevich Sergei Alexandrovich
Hazarnov Veniamine Abramovich
Stankevich Sergei Alexandrovich
Application Number:
JP2020546272A
Publication Date:
March 23, 2022
Filing Date:
December 29, 2018
Export Citation:
Assignee:
オブシェストヴォ ス オグラニチェンノイ オトヴェトストヴェンノスチュ “イノベイティブ ファーマコロジー リサーチ”（“アイピーエイチエーアール”）
International Classes:
C07D243/24
Domestic Patent References:
| JP48044288A | ||||
| JP51098289A | ||||
| JP2002544266A |
Foreign References:
| WO2004106310A1 |
Other References:
Offel, Michael; Lattmann, Pornthip; Singh, Harjit; Billington, D. C.; et al,"Synthesis of substituted 3-anilino-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepine-2-ones and their evaluation as cholecystokinin-ligands",Archiv der Pharmazie,2006年,Vol.339(4),p.163-173
Karaseva, T. L.; Likhota, E. B.; Krivenko, Ya. R.; Semibrat'ev, S. A.; Pavlovskii, V. I.,"Synthesis of New 7-bromo-5-(2'-chlorophenyl)-3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine derivatives and their influence on appetite in rats",Pharmaceutical Chemistry Journal,2017年,Vol.51(4),p.258-261
Pavlovskii, V. I.; Ushakov, I. Yu.; Kabanova, T. A.; Khalimova, E. I.; Kravtsov, V. Kh.; Andronati, S. A.,"Synthesis and Analgesic Activity of 3-Arylamino-1,2-Dihydro-3H-1,4-Benzodiazepin-2-Ones",Pharmaceutical Chemistry Journal,2015年,Vol.49(9),p.592-597
Pavlovsky, V. I.; Tsymbalyuk, O. V.; Martynyuk, V. S.; Kabanova, T. A.; Semenishyna, E. A.; Khalimova, E. I.; Andronati, S. A.,"Analgesic Effects of 3-Substituted Derivatives of 1,4-Benzodiazepines and their Possible Mechanisms",Neurophysiology,2013年,Vol.45(5-6),p.427-432
Makan, S. Yu.; Tkachuk, N. A.; Korkhov, V. M.; Kostenko, S. V.; Boiko, I. et al,"Molecular Targets of New 1,4-Benzodiazepin-2-one Derivatives Influencing the Appetite of Experimental Animals",Pharmaceutical Chemistry Journal,2005年,Vol.39(6),p.300-302
Pavlovsky, V I,"Synthesis and anticonvulsant activity of 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones",Pharmaceutical Chemistry Journal,2012年,Vol.46(9),p.540-545
Andronati, Sergey,"Synthesis, structure and affinity of novel 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones for CNS central and peripheral benzodiazepine receptors",European Journal of Medicinal Chemistry,2010年,Vol.45(4),p.1346-1351
Yang, Shen K.,"Racemization and stereoselective alcoholysis of temazepam",Chirality,1999年,Vol.11(3),p.179-186
Karaseva, T. L.; Likhota, E. B.; Krivenko, Ya. R.; Semibrat'ev, S. A.; Pavlovskii, V. I.,"Synthesis of New 7-bromo-5-(2'-chlorophenyl)-3-arylamino-1,2-dihydro-3H-1,4-benzodiazepine derivatives and their influence on appetite in rats",Pharmaceutical Chemistry Journal,2017年,Vol.51(4),p.258-261
Pavlovskii, V. I.; Ushakov, I. Yu.; Kabanova, T. A.; Khalimova, E. I.; Kravtsov, V. Kh.; Andronati, S. A.,"Synthesis and Analgesic Activity of 3-Arylamino-1,2-Dihydro-3H-1,4-Benzodiazepin-2-Ones",Pharmaceutical Chemistry Journal,2015年,Vol.49(9),p.592-597
Pavlovsky, V. I.; Tsymbalyuk, O. V.; Martynyuk, V. S.; Kabanova, T. A.; Semenishyna, E. A.; Khalimova, E. I.; Andronati, S. A.,"Analgesic Effects of 3-Substituted Derivatives of 1,4-Benzodiazepines and their Possible Mechanisms",Neurophysiology,2013年,Vol.45(5-6),p.427-432
Makan, S. Yu.; Tkachuk, N. A.; Korkhov, V. M.; Kostenko, S. V.; Boiko, I. et al,"Molecular Targets of New 1,4-Benzodiazepin-2-one Derivatives Influencing the Appetite of Experimental Animals",Pharmaceutical Chemistry Journal,2005年,Vol.39(6),p.300-302
Pavlovsky, V I,"Synthesis and anticonvulsant activity of 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones",Pharmaceutical Chemistry Journal,2012年,Vol.46(9),p.540-545
Andronati, Sergey,"Synthesis, structure and affinity of novel 3-alkoxy-1,2-dihydro-3H-1,4-benzodiazepin-2-ones for CNS central and peripheral benzodiazepine receptors",European Journal of Medicinal Chemistry,2010年,Vol.45(4),p.1346-1351
Yang, Shen K.,"Racemization and stereoselective alcoholysis of temazepam",Chirality,1999年,Vol.11(3),p.179-186
Attorney, Agent or Firm:
Nagoya International Patent Service Corporation
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