Title:
17 BETA-ACYL-4-AZA-5 ALPHA-ANDROST-1-ENE-3-ONES BEING 5 ALPHA REDUCTASE INHIBITOR
Document Type and Number:
Japanese Patent JPS63139196
Kind Code:
A
Abstract:
17 beta -Acyl-4-aza-5 alpha -androst-1-en-3-ones of the formula: wherein R is selected from hydrogen, methyl and ethyl R<2> is methoxy, a monovalent radical selected from straight and branched chain alkyl of from 1-12 carbons, or monocyclic aryl optionally containing 1 or more lower alkyl substituents of from 1-2 carbon atoms and/or 1 or more halo (Cl or Br) substituents, aralkyl selected from benzyl and phenethyl and heterocyclic selected from 2- or 4-pyridyl, 2-pyrrolyl, 2-furyl or thiophenyl; and R', R'' and R''' are each selected from hydrogen and methyl and pharmaceutical formulations of the above compounds are active as testosterone 5 alpha -reductase inhibitors and thus are useful for treatment of acne, seborrhea, female hirsutism, and benign prostatic hypertrophy.
Inventors:
GIYARII ETSUCHI RASUMUSON
GUREN EFU REINORUZU
GUREN EFU REINORUZU
Application Number:
JP29221487A
Publication Date:
June 10, 1988
Filing Date:
November 20, 1987
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K31/435; A61P5/00; A61K31/58; A61P13/02; A61P15/00; A61P17/00; C07J73/00; (IPC1-7): A61K31/58; C07J73/00
Attorney, Agent or Firm:
Masao Okabe (3 others)