Title:
D4-アゴニスト活性を有する2-アミノキノリン誘導体
Document Type and Number:
Japanese Patent JP4530535
Kind Code:
B2
Abstract:
The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R1)n represents 1 or 2 substituents, which can be the same or different, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)amino, or two groups R1 at adjacent carbon atoms together with the benzene ring may form the benzdioxane group or benzofuran group, X represents nitrogen or carbon, and the dotted line may represent a double bond, (R2)p represents 0, 1 or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R2)p is a methylene bridge or ethylene bridge, R3 is hydrogen or methyl, and (R)m represents 0, 1, or 2 substituents, which can be the same or different and can be located at all available positions of the quinolyl group, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)amino, on the understanding that R1 cannot represent o-OCH3 when X is nitrogen, (R2)p and R3 are hydrogen, m is 0 and n is 1
Inventors:
Den Hull Talk, Jacobs AJ
Bisser, Guerben M
Van Steen, Bartholomew's Jay
Toulup, Marteinus T.M.
Ronken, Erik
Kruze, Cornelis G
Bisser, Guerben M
Van Steen, Bartholomew's Jay
Toulup, Marteinus T.M.
Ronken, Erik
Kruze, Cornelis G
Application Number:
JP2000530499A
Publication Date:
August 25, 2010
Filing Date:
February 05, 1999
Export Citation:
Assignee:
DUPHAR INTERNATIONAL RESEARCH BESLOTEN VENNOOTSHAP
International Classes:
C07D215/38; A61K31/4709; A61K31/496; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D201/00; C07D401/12; C07D405/12
Domestic Patent References:
| JP2002504125A | ||||
| JP9511527A |
Foreign References:
| WO1997043271A1 | ||||
| US5714487 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office