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Title:
2-NAPHTHYL CARBAPENEMS
Document Type and Number:
Japanese Patent JPH04230384
Kind Code:
A
Abstract:

PURPOSE: To provide new 2-naphthyl carbapenems that are useful intermediate of antibacterial agent.

CONSTITUTION: The compound of formula I, for example, (5R,6S)-2-(1- hydroxymethyl-3-naphtyl)-6-[1R-(allyloxycarbonyl oxy)ethyl]carbapen-2-em-3- carboxylic acid allyl ester is produced by allowing the compound of formula II to react with the compound of formula III. In the formula I, R is H or CH3; R1, R2 are each H, CH3, C2H5, CH(CH3)2, CH2OH, CH(OH)CH3, CH(OH), CH2F, CF2CH3, etc.; Ra is H, CF3, a halogen, alkoxy, OH, O(C=O)R5 {R5 is an alkyl, phenyl, S(O)nR5 [(n) is 0-2]}, azide, formyl, CN, SCN, SCF3, tetrazolyl, etc.; M is H, an esterification group, alkali metal, etc.


Inventors:
FURANKU PII DEINITSUNO
MAAKU ERU GURIINRII
Application Number:
JP17135491A
Publication Date:
August 19, 1992
Filing Date:
July 11, 1991
Export Citation:
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Assignee:
MERCK & CO INC
International Classes:
A61K31/40; A61K31/397; A61P31/04; C07D477/00; C07D477/14; (IPC1-7): A61K31/40; C07D477/00
Domestic Patent References:
JPS5569586A1980-05-26
JPS5387390A1978-08-01
Attorney, Agent or Firm:
Masao Okabe (6 others)