CXCケモカイン受容体リガンドとしての3,4-ジ置換シクロブテン-1,2-ジオン

Japanese Patent JP2009542700

A

Disclosed are novel cyclobutenedione Compounds 1 to 18 comprising a cyclobutenedione ring, a substituted phenyl ring, and a -CH(C₂H₅)-furan moiety. The phenyl ring and the -CH(C₂H₅)-furan moiety are each bound to the cyclobutenedione ring through a -NH- moiety. Also disclosed are methods of treating chemokine mediated diseases (e.g., cancer, COPD, acute and chronic inflammatory disorders, psoriasis, cystic fibrosis, and asthma) using the novel Compounds 1 to 18.

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Chao, Chian Hua
Chalniki, Michael F.
Hey, Chen Min
Rye, Kaifa
Merit, james robert

JP2009518399A

December 03, 2009

July 05, 2007

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Schering Corporation

C07D307/52; A61K31/192; A61K31/198; A61K31/341; A61K31/343; A61K31/365; A61K31/4025; A61K31/405; A61K31/42; A61K31/436; A61K31/454; A61K31/519; A61K31/52; A61K31/5377; A61K31/5415; A61K31/573; A61K31/63; A61K31/635; A61K31/675; A61K31/706; A61K31/727; A61K33/24; A61K38/00; A61K38/21; A61K45/00; A61P1/02; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P17/10; A61P19/02; A61P19/06; A61P19/10; A61P25/00; A61P25/04; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P33/06; A61P35/00; A61P37/06; A61P43/00; C07D307/56; C07D405/12

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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