Title:
4(フェニル-ピペラジニル-メチル)ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用
Document Type and Number:
Japanese Patent JP5028500
Kind Code:
B2
Abstract:
Compounds of general formula I
R 1 is selected from any one of phenyl, furanyl, and pyrrolyl, wherein each of phenyl, pyrrolyl, and furanyl may optionally and independently be substituted by 1 or 2 substituents selected from CF 3 , methyl, chloro, fluoro, bromo, and iodo;
R 2 is independently selected from ethyl and isopropyl;
R 3 is independently selected from hydrogen and fluoro; and
R 4 is -NH 2 ;
or salts thereof or separate enantiomers and salts thereof;
are disclosed and claimed in the present application, as well as separate enantiomers of the compounds and salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.
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Inventors:
William brown
Christopher Walpole
Niklas Probeck
Christopher Walpole
Niklas Probeck
Application Number:
JP2010002450A
Publication Date:
September 19, 2012
Filing Date:
January 08, 2010
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
A61K31/495; A61K31/496; A61P1/00; C07D295/14; A61P1/04; A61P25/04; A61P25/22; A61P29/00; C07D233/24; C07D233/64; C07D233/94; C07D295/155; C07D307/52; C07D307/66; C07D333/20
Domestic Patent References:
| JP7503247A | ||||
| JP2000502679A |
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi