NEW MATERIAL: A compd. represented by formula I [where A-B is CH=CH or CH2-CH2; R1 is H, a 1-4C alkyl, phenyl, benzyl group, an alkali (or an alka line earth) metal ion, etc.; R2-R5 are H, a 1-12C-alkyl group or a 5-7C cycloalkyl which may be optionally linked with an aromatic heterocyclic ring group through a 1-5C alkyl chain (a substd.) phenyl or (a substd.) benzyl group, and a corresponding lactone represented by formula II.
EXAMPLE: Methyl 3(RS),5(RS) -dihydroxy -7 -[1 -phenyl -2,5 -dimethyl-4 -(4 -fluorophenyl) -1H -pyrrol -3 -yl]hept -6(E)-enoate.
USE: EMG-CoA reductase inhibitor.
PREPARATION: Phosfonium salts represented by formula IV, which are obtnd. from a carboaldehye represented by formula III as starting material are allowed to ract with a compactine aldehyde represented by formula V (R10 is a protective group) to obtain a lactol ether represented by formula VI, and then the ether is acid-hydrolized, oxidized and deprotected to obtain a compd. represented by formula II.
| WO/1995/019765 | CERTAIN CERULENIN-GERANYL AND DODECANOIC ACID DERIVATIVES |
| JP6328170 | Therapeutic compound |
GEERUHARUTO BETSUKU
EKEHARUTO BAADAA
BERA KEREKUYARUTO
| JPS63275561A | 1988-11-14 | |||
| JPS49126663A | 1974-12-04 |