8-Culver Moyle 2- (2, 3- Di substitution pyrid 6- Il ) -1 as an apoptosis inducing agent for the medical treatment of cancer, immunopathy, and an autoimmune disease, 2, 3, 4-tetrahydroisoquinoline derivative

Title:

Document Type and Number:

Japanese Patent JP6155270

Kind Code:

B2

Abstract:

Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl; Y1 is phenylene or heteroarylene; L1 is a linker; Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl; Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.

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Inventors:

One, low
Doherty, George
One, seal
Tao, Gee-fu
Swing, milan
Kunzer, Aaron Earl
Went, Michael Dee
Song, Xiao Hong
Frey, Robin
Hansen, Todd Em
Sullivan, Gerrard M
Andrew, Judd
Andrew Sourds

Application Number:

JP2014535869A

Publication Date:

June 28, 2017

Filing Date:

October 11, 2012

Export Citation:

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Assignee:

AbbVie Incorporated

International Classes:

C07D417/14; A61K31/4725; A61K31/4985; A61K31/5025; A61K31/5377; A61K31/541; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D451/02; C07D471/04; C07D487/04; C07D513/04

Foreign References:

WO2010080503A1
WO2010080478A1
WO2011139107A1
WO2013055895A1

Attorney, Agent or Firm:

Kawaguchi International Patent Office

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