Title:
9,10-α,α-OH-タキサンアナログおよびその生成のための方法
Document Type and Number:
Japanese Patent JP4874102
Kind Code:
B2
Abstract:
The present invention relates to new taxane analogs useful for the treatment of cancer as well as methods for producing the same. The chemical compounds according to the present invention have the general Formula (I) wherein R 1 and R 2 are each selected from H, an alkyl group, an olefinic group, an aromatic group, an O-alkyl group, an O-olefinic group, or an O-aromatic group; R 3 is hydroxyl or OP 1 ; R 4 and R 5 are each hydroxyl or R 7 COO; R 6 is hydroxyl, OP 2 , R 7 COO, or an ether functionally; R 7 is an alkyl group, an olefinic group, or an aromatic group; and P 1 and P 2 are each hydroxyl protecting groups. The chemical compounds of the present invention may particularly be 9, 10-±,±-OH taxane analogs that are formed by a process that begins with a standard taxane as the starting compound.
Inventors:
Matchesney, James Dee.
Ferrara, james
Sigmund, Jean
Ferrara, james
Sigmund, Jean
Application Number:
JP2006528316A
Publication Date:
February 15, 2012
Filing Date:
September 27, 2004
Export Citation:
Assignee:
Tapestry Pharmaceuticals, Inc.
International Classes:
C07D305/14; A61K31/337; C07D405/02; C07D493/08; A61P35/00; A61P35/02; A61K
Domestic Patent References:
| JP7505887A |
Other References:
J. Org. Chem.,1998年,Vol.63, No.24,p.8926-8934
Tetrahedron Lett.,1995年,Vol.36, No.12,p.1985-1988
J. Med. Chem.,1995年,Vol.38, No.9,p.1482-1492
J. Org. Chem.,1999年,Vol.64, No.6,p.1814-1822
Tetrahedron Lett.,1993年,Vol.34, No.13,p.2047-2050
J. Org. Chem.,2001年,Vol.66, No.10,p.3330-3337
Tetrahedron Lett.,1995年,Vol.36, No.12,p.1985-1988
J. Med. Chem.,1995年,Vol.38, No.9,p.1482-1492
J. Org. Chem.,1999年,Vol.64, No.6,p.1814-1822
Tetrahedron Lett.,1993年,Vol.34, No.13,p.2047-2050
J. Org. Chem.,2001年,Vol.66, No.10,p.3330-3337
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita