ACTRIIB ANTAGONISTS AND DOSING AND USES THEREOF

Title:

ACTRIIB ANTAGONISTS AND DOSING AND USES THEREOF

Document Type and Number:

Japanese Patent JP2018002730

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide compositions and method for promoting bone growth and mineralization.SOLUTION: The present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma. The present invention also provides a method for dosing a patient with an ActRIIb antagonist. The present invention further provides a method for dosing a patient with an ActRIIb-Fc fusion protein, the method comprising administering an ActRIIb-Fc fusion protein to the patient on a dosing schedule that maintains a serum concentration of the ActRIIb-Fc fusion protein of at least 8 μg/mL.SELECTED DRAWING: None

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Inventors:

JASBIR SEEHRA
JOHN KNOPF
KEN ATTIE

Application Number:

JP2017193336A

Publication Date:

January 11, 2018

Filing Date:

October 03, 2017

Export Citation:

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Assignee:

ACCELERON PHARMA INC

International Classes:

A61K38/16; A61K31/663; A61K45/00; A61P19/00; A61P19/08; A61P21/00; A61P35/00; A61P35/04; A61P43/00; C07K14/71; C07K16/00; C07K19/00

Foreign References:

WO2008076437A2

2008-06-26

Other References:

おくすり１１０番, JPN6019003912, 2 November 2001 (2001-11-02), ISSN: 0003972787

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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