Title:
ACYLAYTION BY ENZYME
Document Type and Number:
Japanese Patent JP3953571
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a (11Z, 13Z)-7,10-dihydro-10-hyroxyretiny acylate which is useful for production of vitamin A acylate under conditions of easy catalyst separation and high yield by acrylating a specific hydroxyretional compound in the presence of an enzymatic catalyst lipase under specific conditions of the acylation.
SOLUTION: This (11Z, 13Z)-7,10-dihydro-10-hyroxyretiny acylate of formula II (R is a 1-23C alkyl or 2-23C alkyl having 1-3 double bonds) is obtained by selectively monoacylating a (11Z, 13Z)-7,10-dihydro-10-hyroxyretinol of formula I with a lipase which is present in a suspension [for example, a suspension of (granulated) diatomaceous earth on which lipase has been fixed, or a suspension of macroporous polyacrylate on which lipase from Candida antarctica has been fixed]. This selective acylation can efficiently prevent formation of undesirable by-products, such as (11Z, 13Z)-7,10-dihydro-10-acetoxyretinyl acetate.
Inventors:
Bernard Orzato
Paul Spur
Beat Wilds
Paul Spur
Beat Wilds
Application Number:
JP9207097A
Publication Date:
August 08, 2007
Filing Date:
April 10, 1997
Export Citation:
Assignee:
DSM IP ASSETS B.V.
International Classes:
C07C35/18; C12N9/20; C12P7/40; C12P7/62; C12P7/64; C12P23/00; (IPC1-7): C07C35/18; C12N9/20; C12P7/40
Domestic Patent References:
| JP1174391A |
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Yoshinori Shimizu
Masakazu Noda
Yoshinori Shimizu
Previous Patent: INORGANIC DECORATIVE PLATE AND ITS MANUFACTURE
Next Patent: MANUFACTURE OF PERFORATED HEADREST SKIN
Next Patent: MANUFACTURE OF PERFORATED HEADREST SKIN