Title:
AGENT FOR PROMOTING CORNEAL ENDOTHELIAL CELL ADHESION
Document Type and Number:
Japanese Patent JP2015013905
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide means whereby corneal endothelial cells can be efficiently proliferated and means whereby a corneal endothelial preparation can be stably supplied.SOLUTION: The invention provides: an agent for promoting corneal endothelial cell adhesion which contains a Rho kinase inhibitor; a culture medium for corneal endothelial cells which contains the Rho kinase inhibitor; a cornea-preserving solution which contains the Rho kinase inhibitor; and a method of producing a corneal endothelial preparation which comprises the step of culturing corneal endothelial cells by using the culture medium; and an agent for protecting corneal endothelium which contains the Rho kinase inhibitor. The agent for promoting corneal endothelial cell adhesion of the invention promotes a corneal endothelial cell adhesion and enables formation of a corneal endothelial cell layer having a good cell form and a high cell density.
Inventors:
KOIZUMI NORIKO
KINOSHITA SHIGERU
UENO MORIO
KINOSHITA SHIGERU
UENO MORIO
Application Number:
JP2014216143A
Publication Date:
January 22, 2015
Filing Date:
October 23, 2014
Export Citation:
Assignee:
SENJU PHARMA CO
KINOSHITA SHIGERU
KINOSHITA SHIGERU
International Classes:
A61K45/00; A61K31/4409; A61K31/4465; A61K31/496; A61K31/551; A61P27/02; A61P43/00
Other References:
JPN6013012912; Ｌｅｅ，Ｊ．Ｇ．，ｅｔ ａｌ．: 'ＦＧＦ-２-Ｉｎｄｕｃｅｄ Ｗｏｕｎｄ Ｈｅａｌｉｎｇ ｉｎ Ｃｏｒｎｅａｌ Ｅｎｄｏｔｈｅｌｉａｌ Ｃｅｌｌｓ Ｒｅｑｕｉｒｅｓ Ｃｄｃ４２ Ａｃｔｉｖａｔｉｏｎ ａｎｄ Ｒｈｏ Ｉｎａｃｔｉｖａｔ' Ｉｎｖｅｓｔ． Ｏｐｈｔｈａｌｍｏｌ． Ｖｉｓ． Ｓｃｉ． Ｖｏｌ．４７，Ｎｏ．４, 200604, ｐｐ．１３７６-１３８６
JPN6013012912; ＬＥＥ，Ｊ．Ｇ．，ｅｔ ａｌ．: 'ＦＧＦ-２-Ｉｎｄｕｃｅｄ Ｗｏｕｎｄ Ｈｅａｌｉｎｇ ｉｎ Ｃｏｒｎｅａｌ Ｅｎｄｏｔｈｅｌｉａｌ Ｃｅｌｌｓ Ｒｅｑｕｉｒｅｓ Ｃｄｃ４２ Ａｃｔｉｖａｔｉｏｎ ａｎｄ Ｒｈｏ Ｉｎａｃｔｉｖａｔ' Ｉｎｖｅｓｔ． Ｏｐｈｔｈａｌｍｏｌ． Ｖｉｓ． Ｓｃｉ． Ｖｏｌ．４７，Ｎｏ．４, 200604, ｐ．１３７６-１３８６
JPN6013012909; ＬＥＥ，Ｈ．Ｔ．，ｅｔ ａｌ．: 'ＦＧＦ-２ ｉｎｄｕｃｅｄ ｒｅｏｒｇａｎｉｚａｔｉｏｎ ａｎｄ ｄｉｓｒｕｐｔｉｏｎ ｏｆ ａｃｔｉｎ ｃｙｔｏｓｋｅｌｅｔｏｎ ｔｈｒｏｕｇｈ ＰＩ ３-ｋｉｎａｓｅ， Ｒｈｏ， ａｎｄ Ｃｄｃ４' Ｍｏｌ． Ｖｉｓ． Ｖｏｌ．９, 20031208, ｐ．６２４-６３４
JPN6013012914; ＳＡＴＰＡＴＨＹ，Ｍ．， ｅｔ ａｌ．: 'Ｔｈｒｏｍｂｉｎ-ｉｎｄｕｃｅｄ ｐｈｏｓｐｈｏｒｙｌａｔｉｏｎ ｏｆ ｔｈｅ ｒｅｇｕｌａｔｏｒｙ ｌｉｇｈｔ ｃｈａｉｎ ｏｆ ｍｙｏｓｉｎ ＩＩ ｉｎ ｃｕｌｔｕｒｅｄ ｂｏｖｉｎｅ ｃｏｒｎｅ' Ｅｘｐ． Ｅｙｅ Ｒｅｓ． Ｖｏｌ．７９，Ｎｏ．４, 200410, ｐ．４７７-４８６
JPN6013012912; ＬＥＥ，Ｊ．Ｇ．，ｅｔ ａｌ．: 'ＦＧＦ-２-Ｉｎｄｕｃｅｄ Ｗｏｕｎｄ Ｈｅａｌｉｎｇ ｉｎ Ｃｏｒｎｅａｌ Ｅｎｄｏｔｈｅｌｉａｌ Ｃｅｌｌｓ Ｒｅｑｕｉｒｅｓ Ｃｄｃ４２ Ａｃｔｉｖａｔｉｏｎ ａｎｄ Ｒｈｏ Ｉｎａｃｔｉｖａｔ' Ｉｎｖｅｓｔ． Ｏｐｈｔｈａｌｍｏｌ． Ｖｉｓ． Ｓｃｉ． Ｖｏｌ．４７，Ｎｏ．４, 200604, ｐ．１３７６-１３８６
JPN6013012909; ＬＥＥ，Ｈ．Ｔ．，ｅｔ ａｌ．: 'ＦＧＦ-２ ｉｎｄｕｃｅｄ ｒｅｏｒｇａｎｉｚａｔｉｏｎ ａｎｄ ｄｉｓｒｕｐｔｉｏｎ ｏｆ ａｃｔｉｎ ｃｙｔｏｓｋｅｌｅｔｏｎ ｔｈｒｏｕｇｈ ＰＩ ３-ｋｉｎａｓｅ， Ｒｈｏ， ａｎｄ Ｃｄｃ４' Ｍｏｌ． Ｖｉｓ． Ｖｏｌ．９, 20031208, ｐ．６２４-６３４
JPN6013012914; ＳＡＴＰＡＴＨＹ，Ｍ．， ｅｔ ａｌ．: 'Ｔｈｒｏｍｂｉｎ-ｉｎｄｕｃｅｄ ｐｈｏｓｐｈｏｒｙｌａｔｉｏｎ ｏｆ ｔｈｅ ｒｅｇｕｌａｔｏｒｙ ｌｉｇｈｔ ｃｈａｉｎ ｏｆ ｍｙｏｓｉｎ ＩＩ ｉｎ ｃｕｌｔｕｒｅｄ ｂｏｖｉｎｅ ｃｏｒｎｅ' Ｅｘｐ． Ｅｙｅ Ｒｅｓ． Ｖｏｌ．７９，Ｎｏ．４, 200410, ｐ．４７７-４８６
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Tsuyoshi Komatani
Natsuki Morishita
Tsuyoshi Komatani
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