To provide a compound targeting prevention and treatment of a disease accompanied by arteriosclerosis, accompanying the elevation of HDL and not accompanying the elevation of TG.
The agent for promoting the elevation of an HDL level in plasma contains a carboxylic acid derivative represented by general formula (I) [wherein, L is a 1-6C alkylene group which may have a substituent, or the like; M is a 1-6C alkylene group which may have a substituent, or the like; T is a 1-3C alkylene group which may have a substituent, or the like; W is a carboxy group; formula (II) represents a single bond or a double bond; X is an oxygen atom or the like; Y is a 5- to 14-membered aromatic group which may have one or more substituents and one or more hetero atoms; ring Z is a 5- to 14-membered aromatic ring which may have one to four substituents; and U is a 5- to 14-membered aromatic ring which may have one to four substituents and one or more heteroatoms, or a single bond], its salt, its ester or a hydrate thereof as an active ingredient.
SHINODA MASANOBU
HIYOSHI HIRONOBU
MATSUURA FUMIYOSHI
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