PURPOSE: To provide the titled suppressing agent having low toxicity and exhibiting strong effect to inhibit the formation of metastatic nest, by using a specific dibenzooxazepine derivative.
CONSTITUTION: The agent contains the compound of formula (R1 and R2 are H or lower alkyl) having excellent lipid metabolizing activity, e.g. ethyl 10,11- dihydro-4-methoxydibenzo[b,f][1,4]oxazepine-8-carboxylate as an active component. The compound of formula has extremely low toxicity (the LD50 of the exemplified compound is ≥45g/kg for mouse), and can be orally administered to a cancered patient for a long period. It can be effectively applied for the prevention of the metastasis of cancer before or after a surgical operation. Dose: ordinary 0.1W10g, preferably 0.3W3g daily for adult by oral or parenteral administration.
KATAOKA SHIGEYUKI
TAKEDA YUMIKO
SUGAWARA YUTAKA
NEICHI TOMOHIRO
HATA SHIYUNICHI
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