To obtain the subject new compound of a medicine suppressing cellular Na+/H- countertransporting body, expressed by a specific formula, especially suitable for the treatment of arrhythmia, manifesting a good cardio-protective effect, and especially suitable for the prevention and treatment of infarct diseases.
This alkenyl-benzoylguanidine derivative is an objective compound of formula I [R1, R2 are each H, a halogen, a 1-6C alkyl, CN, NO2, CF2, CH2F, CHF2, etc.; R3 is-CR5=CR6R7, -C(R6R5)-CR7= CR9R8, etc., a 3-7C cycloalkenyl or a 4-8C cyloalkenylalkyl; R5 to R9 are each H or a 1-6C alkyl], e.g. N-diaminomethylene-2-methyl-4-(1-cyclopenten-3-yl)-5-methylsulfonylbenzamide. Further, in order to obtain the compound, it is preferable to react, etc., a compound of formula II (Q is an easily nucleophilically substitutable leaving group such as Cl or Br) with guanidine.
MANFUREETO BAUMUGARUTO
KURAUSUUOTSUTOO MINKU
NORUBERUTO BAIERU
