Title:
アルキリデンピラゾリジンジオン誘導体並びに糖尿病及び肥満症治療のための使用
Document Type and Number:
Japanese Patent JP2004534072
Kind Code:
A
Abstract:
The present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) for the treatment and/or prevention of diabetes type I and/or II, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity and polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel alkylidene pyrazolidinedione derivatives. (I) R1 and R2 represent independently from each other an unsubstituted or substituted aryl or heteroaryl.
Inventors:
Bonbrün, Anues
Ryukuru, Tomah
Swinen, Dominique
Gonzales, Jerome
Church, dennis
Ryukuru, Tomah
Swinen, Dominique
Gonzales, Jerome
Church, dennis
Application Number:
JP2003504946A
Publication Date:
November 11, 2004
Filing Date:
June 14, 2002
Export Citation:
Assignee:
Applied Research Systems ARS Holding Nam Rosé Fennaught Shap
International Classes:
A61K31/00; A61K31/415; A61K31/4152; A61K31/4155; A61K31/4178; A61K31/4192; A61K31/427; A61K31/4439; A61K31/4709; A61K31/496; A61P3/04; A61P3/10; A61P15/00; A61P15/08; A61P43/00; C07D231/32; C07D401/06; C07D401/10; C07D403/06; C07D405/06; C07D409/06; C07D409/14; C07D417/06; (IPC1-7): C07D231/32; A61K31/4152; A61K31/4155; A61K31/4178; A61K31/427; A61K31/4439; A61K31/4709; A61K31/496; A61P3/04; A61P3/10; A61P15/00; A61P43/00; C07D401/06; C07D403/06; C07D405/06; C07D409/06; C07D417/06
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama