Title:
ＨＤＡＣ８阻害剤としてのアルファ−シンナミド化合物及び組成物
Document Type and Number:
Japanese Patent JP2018531213
Kind Code:
A
Abstract:
本発明は、がん及び他の疾患及び障害の治療に有用であるヒストンデアセチラーゼ、特にＨＤＡＣ８の阻害剤、ならびに該阻害剤の合成及び適用に関する。本発明はＨＤＡＣ８を調節する能力を有する化合物、または薬学的に許容されるそれらの塩もしくは異性体に関し、それらはＨＤＡＣ８の調節に関連する疾患及び障害の治療に有用である。本発明は更に、ＨＤＡＣ８の阻害に有用な化合物、または薬学的に許容されるそれらの塩もしくは異性体に関する。【選択図】なし
Inventors:
Bear, Kenneth W.
Berkzack, Nicholas
Han, Vinson
Lancia, David Earl. Junior
Ryu, Tui Sheng
Martin, Matthew W..
Nguyen, Pui Yi
Radnitskaya, Alexandra
Thomason, Jennifer Earl.
Sabrocchi, Mary-Margaret
Jen, Xiao Chang
Berkzack, Nicholas
Han, Vinson
Lancia, David Earl. Junior
Ryu, Tui Sheng
Martin, Matthew W..
Nguyen, Pui Yi
Radnitskaya, Alexandra
Thomason, Jennifer Earl.
Sabrocchi, Mary-Margaret
Jen, Xiao Chang
Application Number:
JP2017548165A
Publication Date:
October 25, 2018
Filing Date:
March 11, 2016
Export Citation:
Assignee:
FORMA THERAPEUTICS,INC.
International Classes:
C07C239/16; A61K31/16; A61K31/166; A61K31/167; A61K31/17; A61K31/18; A61K31/34; A61K31/341; A61K31/381; A61K31/397; A61K31/40; A61K31/4035; A61K31/404; A61K31/407; A61K31/41; A61K31/415; A61K31/4164; A61K31/4166; A61K31/417; A61K31/4184; A61K31/4188; A61K31/4192; A61K31/42; A61K31/426; A61K31/437; A61K31/438; A61K31/44; A61K31/4439; A61K31/444; A61K31/445; A61K31/4453; A61K31/4468; A61K31/454; A61K31/472; A61K31/495; A61K31/497; A61K31/501; A61K31/505; A61K31/5365; A61K31/5377; A61K31/538; A61K31/54; A61K45/00; A61P1/00; A61P1/04; A61P1/16; A61P3/00; A61P3/04; A61P3/10; A61P7/00; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/14; A61P11/02; A61P11/06; A61P13/02; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/04; A61P21/04; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/14; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P31/14; A61P31/16; A61P31/20; A61P31/22; A61P33/00; A61P33/06; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07D205/04; C07D207/10; C07D207/14; C07D207/27; C07D209/14; C07D209/42; C07D209/44; C07D209/46; C07D211/14; C07D211/18; C07D211/26; C07D211/38; C07D211/54; C07D211/58; C07D211/60; C07D211/96; C07D213/36; C07D213/56; C07D213/65; C07D213/69; C07D213/70; C07D213/74; C07D213/81; C07D213/82; C07D215/12; C07D217/02; C07D221/20; C07D231/12; C07D231/14; C07D231/18; C07D233/34; C07D233/42; C07D233/68; C07D233/72; C07D233/90; C07D235/14; C07D235/30; C07D239/42; C07D241/08; C07D241/12; C07D241/20; C07D241/24; C07D249/18; C07D257/04; C07D261/18; C07D277/28; C07D277/30; C07D277/34; C07D277/42; C07D277/56; C07D277/62; C07D295/135; C07D295/15; C07D295/155; C07D295/185; C07D295/192; C07D295/205; C07D295/26; C07D307/14; C07D307/24; C07D307/68; C07D309/08; C07D317/58; C07D317/60; C07D317/62; C07D333/24; C07D333/34; C07D333/60; C07D333/62; C07D333/70; C07D335/02; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D405/06; C07D405/12; C07D409/04; C07D409/12; C07D417/04; C07D417/12; C07D471/04; C07D471/10; C07D487/04; C07D487/06; C07D487/10; C07D491/107; C07D493/06; C07D497/10; C07D498/04
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto