To provide a pharmaceutical composition capable of exhibiting excellent antiproliferative activity on activated lymphocyte cells and useful as a prophylactic or remedy for various autoimmune diseases.
This pharmaceutical composition contains an amide compound expressed by the general formula (I) (R1 is a substituted aryl, a heteroaryl or the like; R2 and R3 are each H, an alkyl, a halogen, hydroxy, an alkoxy, amino or the like; Q is N, CH or the like; W is H, an alkyl, a hydroxycarbonylalkyl or the like; X is a halogen, cyano, nitro, amino, an alkyl, an alkoxy, carboxy, an alkoxycarbonyl or the like; X' is H, a halogen, cyano or nitro; Y is an alkyl, a hydroxyalkyl, a hydroxycarbonylalkyl, an aminoalkyl, hydroxy, an alkoxy, a hydroxyalkoxy, a hydroxycarbonylalkoxy, an aminoalkoxy, mercapto, an alkylthio, a hydroxyalkylthio, a hydroxycarbonylalkylthio, an aminoalkylthio, a cyclic amino or the like) or its salt as an active ingredient.
ISHIBUCHI SEIGOU
NAITO YOICHIRO
SUGIYAMA NAOKI
KAWAGUCHI TAKASHI
CHIBA KENJI
OTSUKI MAKIO
NAKA YOICHI
| US4134987A | 1979-01-16 | |||
| US4134987A | 1979-01-16 |
JPN6010022517, Ｃｌｉｎ．Ｅｘｐ．Ｉｍｍｕｎｏｌ．, 1993, ９４（２）, ｐｐ．３７１−３７６
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