ナトリウム−グルコース結合輸送体阻害剤のアミン溶媒和物、その調製方法およびその適用

Title:

ナトリウム−グルコース結合輸送体阻害剤のアミン溶媒和物、その調製方法およびその適用

Document Type and Number:

Japanese Patent JP6965274

Kind Code:

B2

Abstract:

Disclosed are an amine solvate of a sodium-glucose linked transporter (SGLT) inhibitor, and a preparation method and application thereof. The SGLT inhibitor is (1 S ,2 S ,3 S ,4 R ,5 S )-5-(3-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-ethylbenzyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol. Further provided is a crystalline compound of the amine solvate, a pharmaceutical composition comprising the amine solvate, and an application of the amine solvate in preparing an SGLT-inhibiting pharmaceutical product.

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Inventors:

Chang Lei
One Yuan

Application Number:

JP2018557028A

Publication Date:

November 10, 2021

Filing Date:

March 27, 2017

Export Citation:

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Assignee:

YOUNGENE THERAPEUTICS CO., LTD.

International Classes:

C07H7/06; A61K31/7004; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P13/12; A61P25/02; A61P27/02; A61P43/00

Domestic Patent References:

JP2003530396A

Foreign References:

WO2015032272A1

Other References:

浅原照三編,溶剤ハンドブック,株式会社講談社,1985年9月1日,第6刷,p.47~51

Attorney, Agent or Firm:

Kenji Sugimura
Mitsutsugu Sugimura
Takao Inoue

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