To obtain an amino alcohol derivative having activity on stimulating or controlling the biosynthesis of a glycolipid, antitumor activity, and activities suppressing cancer metastasis and stimulating the growth of neurocyte, and useful as a synthetic intermediate of a PDMT analog.
A 2-acylaminoalcohol expressed by formula I (the mark *indicates an asymmetric carbon; R1 is an alkyl, a cycloalkyl, etc.; R2 is a group of formula II, etc.; R11 is a 3-18C alkyl or alkenyl), e.g. (1S,2S)-2- benzyloxycarbonylamino-1-phenyl-1,3-propanediol-3-methanesulfonyl ester. A compound of formula I is obtained by reacting an aminopropanol derivative expressed by formula III (P1 is an alkyl or an amino-protecting group; Y is a leaving group) with an amine, removing the P1 group from the reaction product to obtain an amino alcohol derivative and further reacting the amino alcohol derivative with carboxylic acid or its reactive derivative.
OYAMADA HIDEKAZU
INOKUCHI JINICHI
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