Title:
AMYLOID BETA AGGREGATION DEPRESSANT
Document Type and Number:
Japanese Patent JP2014224132
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an agent depressing aggregation of amyloid beta caused by GNE gene mutation.SOLUTION: A therapeutic drug according to the present invention is characterized by comprising a compound effective for increasing the amount of N-acetylneuraminic acid in a cell. The compound contained in the therapeutic drug includes N-acetylneuraminic acid, an intermediate product produced downstream of N-acetylmannosamine in N-acetylneuraminic acid biosynthetic pathway, an N-acetylneuraminic acid derivative, an N-acetylmannosamine derivative, an N-acetylneuraminic acid-containing compound, an N-acetylneuraminic acid derivative-containing compound, an N-acetylmannosamine-containing compound, an N-acetylmannosamine derivative-containing compound, a catabolic enzyme inhibitory substance of N-acetylneuraminic acid, a catabolic enzyme inhibitory substance of N-acetylmannosamine, a catabolic enzyme inhibitory substance of the intermediate product, and the like.
Inventors:
NOGUCHI SATORU
MAY CHRISTINE MALICDAN
NISHINO KAZUMI
MAY CHRISTINE MALICDAN
NISHINO KAZUMI
Application Number:
JP2014148160A
Publication Date:
December 04, 2014
Filing Date:
July 18, 2014
Export Citation:
Assignee:
JAPAN HEALTH SCIENCE FOUND
International Classes:
A61K31/7008; A23L1/30; A61K31/7012; A61K31/702; A61P21/00; A61P43/00
Domestic Patent References:
| JP2001240599A | 2001-09-04 | |||
| JP2003292444A | 2003-10-15 |
Foreign References:
| WO2008150477A2 | 2008-12-11 | |||
| WO1998006418A1 | 1998-02-19 |
Other References:
縁取り空胞を伴う遠位型ミオパチーの根本的治療法開発 平成19年度 総括・分担研究報告書, JPN6010033583, April 2008 (2008-04-01), pages 1 - 7, ISSN: 0003111462
縁取り空胞を伴う遠位型ミオパチーの根本的治療法開発 平成19年度 総括・分担研究報告書, JPN6010033584, April 2008 (2008-04-01), pages 8 - 11, ISSN: 0003111463
MARJAN HUIZING ET AL.: "N-acetylmannosamine treatment rescues a mouse model of hereditary inclusion body myopathy", GLYCOBIOLOGY, vol. 16, no. 11, JPN6010033585, November 2006 (2006-11-01), pages 1110 - 1111, XP009108903, ISSN: 0003111464
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 12, JPN6015027530, 2004, pages 11402 - 11407, ISSN: 0003111465
縁取り空胞を伴う遠位型ミオパチーの根本的治療法開発 平成19年度 総括・分担研究報告書, JPN6010033584, April 2008 (2008-04-01), pages 8 - 11, ISSN: 0003111463
MARJAN HUIZING ET AL.: "N-acetylmannosamine treatment rescues a mouse model of hereditary inclusion body myopathy", GLYCOBIOLOGY, vol. 16, no. 11, JPN6010033585, November 2006 (2006-11-01), pages 1110 - 1111, XP009108903, ISSN: 0003111464
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 12, JPN6015027530, 2004, pages 11402 - 11407, ISSN: 0003111465
Attorney, Agent or Firm:
Patent business corporation MAEDA PATENT OFFICE
Previous Patent: STABLE FAT EMULSION COMPRISING PROSTAGLANDIN E1
Next Patent: METHOD OF DIAGNOSING AND TREATING DYSPHAGIA
Next Patent: METHOD OF DIAGNOSING AND TREATING DYSPHAGIA