Title:
ANDROGEN RECEPTOR MODULATOR FOR TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES
Document Type and Number:
Japanese Patent JP2014133755
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a series of compounds that modulate the function of the nuclear hormone receptors, especially the androgen receptor.SOLUTION: The present invention relates to hydantoin compounds, methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example, prostate cancer, and to pharmaceutical compositions containing such compounds. In an embodiment, a pharmaceutical composition includes a therapeutically effective amount of a compound according to the formula II, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or adjuvant. The present invention provides a series of compounds that modulate the function of the nuclear hormone receptors, especially the androgen receptor. These compounds can cause disappearance of prostate cancer cells and tumors.
Inventors:
JUNG MICHAEL E
SAWYERS CHARLES L
OUK SAMEDY
TRAN CHRIS
WONGVIPAT JOHN
SAWYERS CHARLES L
OUK SAMEDY
TRAN CHRIS
WONGVIPAT JOHN
Application Number:
JP2014083382A
Publication Date:
July 24, 2014
Filing Date:
April 15, 2014
Export Citation:
Assignee:
UNIV CALIFORNIA
International Classes:
C07D401/04; A61K9/10; A61K9/14; A61K9/20; A61K9/48; A61K31/4439; A61K47/02; A61K47/20; A61K47/34; A61K47/38; A61P35/00; A61P43/00; A61K9/08
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita
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