Title:
ANDROGEN SYNTHESIS INHIBITOR
Document Type and Number:
Japanese Patent JP2010024238
Kind Code:
A
Abstract:
To provide an enzyme inhibitor strongly inhibiting 17-hydroxylase/C17,20-lyase and 5-reductase, blocking all androgen synthesis, and useful in treatment of prostatic cancer and benign prostatic hypertrophy, based on defects associated with synthetic inhibitors of prior arts.
There are provided new inhibitors of androgen synthesis that are useful in the treatment of prostatic cancer and benign prostatic hypertrophy. Also there are provided methods of synthesizing the new compounds, pharmaceutical compositions containing the new compounds, and methods of treating prostatic cancer and benign prostatic hypertrophy by using the androgen synthesis inhibitors.
Inventors:
BRODIE ANGELA
LING YANGZHI
LING YANGZHI
Application Number:
JP2009249032A
Publication Date:
February 04, 2010
Filing Date:
October 29, 2009
Export Citation:
Assignee:
UNIV MARYLAND
International Classes:
A61K31/565; C07J73/00; A61K31/57; A61K31/58; A61K31/715; A61P13/08; A61P35/00; A61P43/00; C07J7/00; C07J13/00; C07J41/00; C07J43/00
Foreign References:
| WO1993023039A1 | 1993-11-25 | |||
| US2707189A | 1955-04-26 |
Other References:
JPN6012036981; Ｂｉｏｃｈｉｍｉｃａ ｅｔ Ｂｉｏｐｈｙｓｉｃａ Ａｃｔａ， Ｅｎｚｙｍｏｌｏｇｙ Ｖｏｌ．３１５， Ｎｏ．２, 1973, ｐ．２３３-２４９
JPN6012036982; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．８０， Ｎｏ．７, 1991, ｐ．６６１-６６４
JPN6012036982; Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．８０， Ｎｏ．７, 1991, ｐ．６６１-６６４
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei