アンドロスタンおよびプレグナン系列の神経活性ステロイド

Japanese Patent JP4145350

B2

The invention relates to a 3 alpha -hydroxy, 17-(un)substituted derivatives of the androstane series and 3 alpha -hydroxy, 21-substituted derivatives of the pregnane series. These derivatives are capable of acting at the recently identified site on the GRC, thereby modulating brain excitability in a manner that will alleviate stress, anxiety, insomnia, mood disorders that are amenable to GRC-active agents (such as depression) and seizure activity. The steroid derivatives of this invention are those having general structural formula (I), wherein R, R1, R2, R3,R4, R5, R6, R7, R8, R9 and R10 are further defined herein and the dotted lines are single or double bonds. The structure includes androstanes pregnanes (R4 = methyl), 19-norandrostanes, and norpregnanes (R4=H).

JPH04505328	[Title of the Invention] Osmotic pressure dosage forms
JP2834721	[Title of the Invention] A 17α-cyanomethylestra-4,9-diene derivative, a method for producing the same, and a pharmaceutical product containing the compound.
JP2001515038	INDUSTRIAL APPLICABILITY: Methods for preventing or treating estrogen-dependent diseases and disorders.

Rabindra Bee, Apa Sani
Fick, David Bee
Hogenkamp, Dark Jay
Orchid, nancy see

JP50221097A

September 03, 2008

June 06, 1996

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Euro-Celtic S.A.

A61K31/565; A61K31/57; C07J1/00; A61P25/00; A61P25/20; A61P25/22; A61P25/24; C07J5/00; C07J17/00; C07J21/00; C07J31/00; C07J41/00; C07J43/00

JP6501962A

Steroids, 1965年, Vol.5, No.5, p.557-583
Steroids, 1986年, Vol.48, Nos.5-6, p.339-346
Molecular Pharmacology, 1990年, Vol.37, No.3, p.429-434

Aoyama Aoi
Kyousei Tamura
Hiromitsu Takayama
Minato Saito

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