Title:
ANGIOGENESIS METHOD AND ANGIOGENESIS AGENT
Document Type and Number:
Japanese Patent JP2005336102
Kind Code:
A
Abstract:
To provide an effective angiogenesis method and angiogenesis agent applying little load on the patient.
The angiogenesis method comprises the irradiation of the treating site with low dose of radiation, and the angiogenesis agent contains a radioactive substance. For example, the blood vessel of a patient is safely formed by applying a low-dose radiation of 0.6-6.5 Gy.
Inventors:
HATTORI KOICHI
BEATE HEIDI
BEATE HEIDI
Application Number:
JP2004157222A
Publication Date:
December 08, 2005
Filing Date:
May 27, 2004
Export Citation:
Assignee:
LINK GENOMICS KK
International Classes:
A61N5/10; A61K33/24; A61K33/38; A61K38/00; A61P9/00; A61P9/10; (IPC1-7): A61K33/24; A61K33/38; A61K38/00; A61N5/10; A61P9/00; A61P9/10
Other References:
JPN6010050650, Ｍｅｌａｎｉｅ Ｃ． Ｗｅｒｇｉｎ ｅｔ ａｌ, "Ｐｒｅｌｉｍｉｎａｒｙ ｓｔｕｄｙ ｏｆ ｐｌａｓｍａ ｖａｓｃｕｌａｒ ｅｎｄｏｔｈｅｌｉａｌ ｇｒｏｗｔｈ ｆａｃｔｏｒ （ＶＥＧＦ） ｄｕｒｉｎｇ ｌｏｗ− ａｎｄ ｈｉｇｈ−ｄｏｓｅ ｒａｄｉ", Ｖｅｔｅｒｉｎａｒｙ Ｒａｄｉｏｌｏｇｙ ＆ Ｕｌｔｒａｓｏｕｎｄ, 20040525, ４５， ３, ｐ．２４７−２５４
JPN7010002762, Ｐａｒｔｈｙｍｏｕ， Ａ, "Ｉｒｒａｄｉａｔｉｏｎ ｏｆ Ｃ６ Ｇｌｉｏｍａ Ｃｅｌｌｓ ｗｉｔｈ Ｘ Ｒａｙｓ Ｉｎｃｒｅａｓｅｓ ｔｈｅ Ｅｘｐｒｅｓｓｉｏｎ ｏｆ Ａｎｇｉｏｇｅｎｉｃ Ｇｅｎｅｓ ａｎｄ ｔｈｅｉｒ Ａｎ", Ｒｅｖｉｅｗ ｏｆ Ｃｌｉｎｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ, 20040412, １８， １, ｐ．１６５−１６６
JPN6010050651, 後藤信司他, "放射線と血管新生", 原子爆弾後障害研究会特集号（長崎医学会雑誌）, 1998, ７３, ｐ．２９４−２９７
JPN6010050652, Ｈｉｌｄｅｂｒａｎｄｔ Ｇ ｅｔ ａｌ, "Ｅｆｆｅｃｔｓ ｏｆ ｌｏｗ ｄｏｓｅ ｉｏｎｉｚｉｎｇ ｒａｄｉａｔｉｏｎ ｏｎ ｍｕｒｉｎｅ ｃｈｒｏｎｉｃ ｇｒａｎｕｌｏｍａｔｏｕｓ ｔｉｓｓｕｅ", Ｓｔｒａｈｌｅｎｔｈｅｒａｐｉｅ ｕｎｄ Ｏｎｋｏｌｏｇｉｅ, 1998, １７４， １１, ｐ．５８０−５８８
JPN6010050653, Ｊｏｎｇ−Ｓｕｎｇ Ｐａｒｋ ｅｔ ａｌ, Ｏｎｃｏｇｅｎｅ, 2001, ２０, ｐ．３２６６−３２８０
JPN7010002763, Ｈｅｉｓｓｉｇ， Ｂｅａｔｅ, "ＭＭＰ−９−Ｍｅｄｉａｔｅｄ Ａｃｔｉｖａｔｉｏｎ ａｎｄ Ｒｅｌｅａｓｅ ｏｆ Ｐｒｏ−Ａｎｇｉｏｇｅｎｉｃ Ｆａｃｔｏｒｓ Ｆｏｌｌｏｗｉｎｇ Ｉｒｒａｄｉａｔｉｏｎ", Ｂｌｏｏｄ, 20030806, Ｖｏｌ． １００， Ｎｏ． １１, Ａｂｓｔｒａｃｔ Ｎｏ． ４６１
JPN6010050654, Ｓｏｎｖｅａｕｘ， Ｐｉｅｒｒｅ ｅｔ ａｌ, "Ｉｒｒａｄｉａｔｉｏｎ−ｉｎｄｕｃｅｄ Ａｎｇｉｏｇｅｎｅｓｉｓ ｔｈｒｏｕｇｈ ｔｈｅ Ｕｐ−Ｒｅｇｕｌａｔｉｏｎ ｏｆ ｔｈｅ Ｎｉｔｒｉｃ Ｏｘｉｄｅ Ｐａｔｈｗａｙ： Ｉｍｐｌｉｃａｔｉｏｎｓ", Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ, 2003, ６３， ５, ｐ．１０１２−１０１９
JPN7010002762, Ｐａｒｔｈｙｍｏｕ， Ａ, "Ｉｒｒａｄｉａｔｉｏｎ ｏｆ Ｃ６ Ｇｌｉｏｍａ Ｃｅｌｌｓ ｗｉｔｈ Ｘ Ｒａｙｓ Ｉｎｃｒｅａｓｅｓ ｔｈｅ Ｅｘｐｒｅｓｓｉｏｎ ｏｆ Ａｎｇｉｏｇｅｎｉｃ Ｇｅｎｅｓ ａｎｄ ｔｈｅｉｒ Ａｎ", Ｒｅｖｉｅｗ ｏｆ Ｃｌｉｎｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ, 20040412, １８， １, ｐ．１６５−１６６
JPN6010050651, 後藤信司他, "放射線と血管新生", 原子爆弾後障害研究会特集号（長崎医学会雑誌）, 1998, ７３, ｐ．２９４−２９７
JPN6010050652, Ｈｉｌｄｅｂｒａｎｄｔ Ｇ ｅｔ ａｌ, "Ｅｆｆｅｃｔｓ ｏｆ ｌｏｗ ｄｏｓｅ ｉｏｎｉｚｉｎｇ ｒａｄｉａｔｉｏｎ ｏｎ ｍｕｒｉｎｅ ｃｈｒｏｎｉｃ ｇｒａｎｕｌｏｍａｔｏｕｓ ｔｉｓｓｕｅ", Ｓｔｒａｈｌｅｎｔｈｅｒａｐｉｅ ｕｎｄ Ｏｎｋｏｌｏｇｉｅ, 1998, １７４， １１, ｐ．５８０−５８８
JPN6010050653, Ｊｏｎｇ−Ｓｕｎｇ Ｐａｒｋ ｅｔ ａｌ, Ｏｎｃｏｇｅｎｅ, 2001, ２０, ｐ．３２６６−３２８０
JPN7010002763, Ｈｅｉｓｓｉｇ， Ｂｅａｔｅ, "ＭＭＰ−９−Ｍｅｄｉａｔｅｄ Ａｃｔｉｖａｔｉｏｎ ａｎｄ Ｒｅｌｅａｓｅ ｏｆ Ｐｒｏ−Ａｎｇｉｏｇｅｎｉｃ Ｆａｃｔｏｒｓ Ｆｏｌｌｏｗｉｎｇ Ｉｒｒａｄｉａｔｉｏｎ", Ｂｌｏｏｄ, 20030806, Ｖｏｌ． １００， Ｎｏ． １１, Ａｂｓｔｒａｃｔ Ｎｏ． ４６１
JPN6010050654, Ｓｏｎｖｅａｕｘ， Ｐｉｅｒｒｅ ｅｔ ａｌ, "Ｉｒｒａｄｉａｔｉｏｎ−ｉｎｄｕｃｅｄ Ａｎｇｉｏｇｅｎｅｓｉｓ ｔｈｒｏｕｇｈ ｔｈｅ Ｕｐ−Ｒｅｇｕｌａｔｉｏｎ ｏｆ ｔｈｅ Ｎｉｔｒｉｃ Ｏｘｉｄｅ Ｐａｔｈｗａｙ： Ｉｍｐｌｉｃａｔｉｏｎｓ", Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ, 2003, ６３， ５, ｐ．１０１２−１０１９
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Eiji Katayama
Junko Kobayashi
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