To obtain the new subject compound useful for prevention and treatment of inflammatory disease, allergic disease, tissue injury or the like as a Ca2+ release activated Ca2+ channel(CRACC) inhibitor having high CRACC selectivity to a membrane potential-dependent Ca2+ channel.
This new compound is the one of formula I [Ra is OH, O-(a lower alkyl) or the like; Rb, Rc and Rd are each H, a halogen or the like; Re is H or a lower alkyl; Rf is H, NO2 or the like; X is CO or CH2; with the proviso that when Ra is OH, Rd is OMe, Re is H and X is CO, Rf is Cl, and when Ra is OH, Rb is Br, Re is H and X is CO, Rf is H or the like, and so on], e.g. 3-bromo-4',5-dichloro-2-methoxybenzanilide. The compound of formula I is obtained by reacting a carboxylic acid of formula H or a reactive derivative, with an amino derivative of formula II. When the carboxylic acid is reacted as it is, the reaction is preferably carried out in the presence of a condensing agent.
FUNATSU MASASHI
SUGASAWA KEIZOU
ISHIKAWA ATSUSHI
TAKEUCHI MAKOTO
