ANT-EGFR SINGLE-STRANDED FV AND ANTI-EGFR ANTIBODY

Title:

ANT-EGFR SINGLE-STRANDED FV AND ANTI-EGFR ANTIBODY

Document Type and Number:

Japanese Patent JP2006025794

Kind Code:

A

Abstract:

To provide new anti-EGFR antibodies and single-stranded Fvs (scFvs) thereof which can be obtained from phage-antibody libraries constructed from cells of an immunized mammalian, preferably a mouse.

Two of the single-stranded Fvs isolated from the phage-antibody libraries are genetically engineered to create partially humanized whole antibody molecules. These chimeric anti-EGFR antibodies contain constant regions of human immunoglobulins, and can be used as well as the single-stranded Fvs as agents for the diagnosis and therapy of human tumors.

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Inventors:

KETTLEBOROUGH A CATHRINE
BENDIG MARY M
ANSELL KEITH H
GUESSOW DETLEF
ADAN JAUME
MITJANS FRANCESC
ROSELL ELISABET
BLASCO FRANCESC
PIULATS JAUME

Application Number:

JP2005233093A

Publication Date:

February 02, 2006

Filing Date:

August 11, 2005

Export Citation:

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Assignee:

MERCK PATENT GMBH

International Classes:

C12N15/09; G01N33/53; A61K39/395; A61P35/00; C07K16/00; C07K16/28; C07K16/46; C12N15/13; C12P21/02; C12P21/08; G01N33/563; A61K38/00; C12R1/19

Attorney, Agent or Firm:

Akio Miyazaki
Ishibashi Masayuki
Shinichi Iwata
Masaaki Ogata

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