Title:
ANTI-CONNEXIN POLYNUCLEOTIDE AS IMPAIRED WOUND HEALING COMPOSITION
Document Type and Number:
Japanese Patent JP2015063565
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide anti-connexin polynucleotides as impaired wound healing compositions.SOLUTION: There are provided connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles. The present invention in one embodiment provides for increases and improvements in the healing of wounds that do not heal at expected rates, such as delayed-healing wounds, incompletely healing wounds, and chronic wounds, through the use of one or more connexin antisense polynucleotides. In one aspect, the invention comprises a synthetic or naturally occurring wound healing matrix comprising an anti-connexin polynucleotide. In certain embodiments, the anti-connexin polynucleotide is an anti-connexin 43 polynucleotide, for example, an anti-connexin 43 polynucleotide.
Inventors:
BECKER DAVID L
GREEN COLIN R
DUFT BRADFORD J
GREEN COLIN R
DUFT BRADFORD J
Application Number:
JP2015000248A
Publication Date:
April 09, 2015
Filing Date:
January 05, 2015
Export Citation:
Assignee:
CODA THERAPEUTICS INC
International Classes:
A61K31/7088; A61K9/70; A61K31/7105; A61K31/713; A61K48/00; A61L15/44; A61P17/02; A61P43/00; C12N15/113
Domestic Patent References:
| JP2002535377A | 2002-10-22 |
Other References:
JOURNAL OF CELL SCIENCE, 2003, VOL.116(6), P.3443-3452, JPN6016033369, ISSN: 0003389856
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto