PURPOSE: To obtain the anti-pancreatitic agent containing an aromatic amidine derivative or its salt as an active ingredient, having an excellent anti- pancreatitic action, and little in side effects.
CONSTITUTION: The anti-pancreatitic agent contains a compound of formula I (R1 is H, alkoxy; R2 is H, alkyl, alkoxy, carboxyl, alkoxycarbonyl, carboxyalkyl, alkoxycarbonylalkyl; R3 is H, carboxyl, alkoxycarbonyl, carboxyalkyl, carboxyalkoxy, etc.; R4 is H, OH, alkyl, alkoxy; n is 0-4; A is 1-4C alkylene which may be substituted with one or two of hydroxyalkyl groups, carboxyl groups, etc.; X is single bond, O, S, CO; Y is 5 or 6-membered cyclic hydrocarbon group, 5 or 6-membered heterocyclic group, NH2, etc.; the group of formula II is indolyl, indolinyl, benzothienyl, naphthyl, etc.,), e.g. 2-[4-[(1- acetoamidoyl-3-pyrrolidinyl)oxy]phenyl]-3-(7-amidino-2-naphthyl)propionic acid, as an active ingredient.
TABUCHI YOSHIAKI
OOTSUBO RIRA
