Title:
ANTI-UREAPLASMA AGENT
Document Type and Number:
Japanese Patent JP3905563
Kind Code:
B2
Abstract:
PURPOSE: To obtain an anti-ureaplasma agent containing a benzimidazole compound having a specific structure as an active component, effectively inhibiting the proliferation of microorganism of the genus Ureaplasma in high selectively and useful as an agent for the treatment of nongonococcal urethritis, chronic prostatitis, etc.
CONSTITUTION: This anti-ureaplasma agent contains a benzimidazole compound having (2-pyridyl)methylthio structure in the molecule as an active component. The microorganism of the genus Ureaplasma is especially Ureaplasma ureaticum. The benzimidazole compound is preferably a compound of formula I (ring A may have substituent; R1 and R3 are each H, an alkyl or an alkoxy; R2 is a hydrocarbon group) or its salt or a compound of formula II (ring A' may have substituent; R1' and R3' are each H, an alkyl or an alkoxy; R2' is a hydrocarbon group; X- is an anion). The benzimidazole is especially preferably 5-hydroxy-2-[2-[3-methyl-4-(2,2,2-trifluoroethoxy)pyridyl]methylsulfinyl]- benzimidazole.
Inventors:
Kumiko Nagata
Toshihide Tamura
Hiroshi Sato
Toshihide Tamura
Hiroshi Sato
Application Number:
JP31360094A
Publication Date:
April 18, 2007
Filing Date:
December 16, 1994
Export Citation:
Assignee:
Takeda GmbH
International Classes:
A61K31/44; C07D401/12; A61K31/4427; A61K31/54; A61K31/549; A61P31/04; C07D513/14; (IPC1-7): A61K31/44; A61K31/54; C07D401/12; C07D513/14
Other References:
KUMIKO NAGATA,et al,Potent Inhibitory Action of the Gastric ProtonPump Inhibitor Lansoprazole against Urease Activity of,Antimicrob.Agents.Chemother.,1993年 4月,Vol.37,No.4,769-774
A. BLANCHARD,et al,Characteristics of Ureaplasma urealyticum Urease.,J.Bacteriol.,1988年 6月,Vol.170,No.6,2692-2697
HARRY L.T.MOBLEY,et al.,Characterization of Urease from Campylobacter pyroli.,J.Clin.Microbiol.,1988年 5月,Vol.26,No.5,831-836
A. BLANCHARD,et al,Characteristics of Ureaplasma urealyticum Urease.,J.Bacteriol.,1988年 6月,Vol.170,No.6,2692-2697
HARRY L.T.MOBLEY,et al.,Characterization of Urease from Campylobacter pyroli.,J.Clin.Microbiol.,1988年 5月,Vol.26,No.5,831-836
Attorney, Agent or Firm:
Yo Sekiguchi
Shuichi Takahashi
Tadao Asahina
Shuichi Takahashi
Tadao Asahina