Title:
ANTIBODIES TO M-CSF
Document Type and Number:
Japanese Patent JP2015147802
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide isolated human antibodies or antigen-binding portions thereof that specifically bind to human M-CSF and act as an M-CSF antagonist, and to provide compositions comprising such antibodies or antigen-binding portions thereof.SOLUTION: The invention provides antibodies that specifically bind to a M-CSF, preferably to human M-CSF and that function to inhibit the M-CSF, antigen-binding portions thereof, human anti M-CSF antibodies and antigen binding portions thereof, as well as compositions comprising the antibodies or antigen binding portions thereof, and nucleic acid molecules encoding compounds constituting the composition. The invention also provides methods for preparing human anti M-CSF antibodies and compositions comprising the antibodies, methods for using the antibodies and the compositions in diagnosis and treatment, and gene therapies using the nucleic acid molecules encoding the heavy chain and/or light chain of immunoglobulin molecules comprising the human anti M-CSF antibodies.
Inventors:
BEDIAN VAHE
DEVALARAJA MADHAV NARASIMHA
LOW JOSEPH EDWIN
MOBLEY JAMES LESLIE
KELLERMANN SIRID-AIMEE
FOLTZ IAN
HAAK-FRENDSCHO MARY
DEVALARAJA MADHAV NARASIMHA
LOW JOSEPH EDWIN
MOBLEY JAMES LESLIE
KELLERMANN SIRID-AIMEE
FOLTZ IAN
HAAK-FRENDSCHO MARY
Application Number:
JP2015097050A
Publication Date:
August 20, 2015
Filing Date:
May 12, 2015
Export Citation:
Assignee:
WARNER LAMBERT CO
AMGEN FREMONT INC
AMGEN FREMONT INC
International Classes:
C07K16/24; A61K39/395; A61P1/04; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P21/00; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P33/06; A61P35/00; A61P37/06; C07K14/47; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12P21/08; G06Q30/00; G06F
Domestic Patent References:
| JP2002537226A | 2002-11-05 |
Foreign References:
| WO1998046644A1 | 1998-10-22 | |||
| WO2000035956A1 | 2000-06-22 | |||
| WO2005030124A2 | 2005-04-07 |
Other References:
J. LEUKOCYTE BIOL., vol. 68, no. 1, JPN4006019761, July 2000 (2000-07-01), pages 144 - 150, ISSN: 0003300296
YANG, W., ET AL., CHINESE JOURNAL OF CANCER RESEARCH, vol. 11, no. 2, JPN4006019762, 1999, pages 79 - 84, ISSN: 0003300297
INFECTION AND IMMUNITY, vol. 70, no. 9, JPN4006019763, September 2002 (2002-09-01), pages 4977 - 4986, ISSN: 0003300298
JOURNAL OF LEUKOCYTE BIOLOGY, vol. 62, JPN6010041059, August 1997 (1997-08-01), pages 145 - 155, ISSN: 0003300299
ANALYTICAL CHEMISTRY, vol. 66, no. 5, JPN4006019764, 1 March 1994 (1994-03-01), pages 585 - 595, ISSN: 0003300300
BLOOD, vol. 82, no. 10, JPN6010041057, 15 November 1993 (1993-11-15), pages 3170 - 3176, ISSN: 0003491500
YANG, W., ET AL., CHINESE JOURNAL OF CANCER RESEARCH, vol. 11, no. 2, JPN4006019762, 1999, pages 79 - 84, ISSN: 0003300297
INFECTION AND IMMUNITY, vol. 70, no. 9, JPN4006019763, September 2002 (2002-09-01), pages 4977 - 4986, ISSN: 0003300298
JOURNAL OF LEUKOCYTE BIOLOGY, vol. 62, JPN6010041059, August 1997 (1997-08-01), pages 145 - 155, ISSN: 0003300299
ANALYTICAL CHEMISTRY, vol. 66, no. 5, JPN4006019764, 1 March 1994 (1994-03-01), pages 585 - 595, ISSN: 0003300300
BLOOD, vol. 82, no. 10, JPN6010041057, 15 November 1993 (1993-11-15), pages 3170 - 3176, ISSN: 0003491500
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi
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