PURPOSE: To obtain an anticomplementary substance composed of a specified phenolic compound and capable of remarkably inhibiting the classical activating pathway of a complementary reaction.
CONSTITUTION: This anticomplementary substance is composed of a compound selected from gallic acid, methyl gallate, acetylsalicylic acid, coffeic acid, catechin, epigallocatechin-gallate, myricetin, quercitrin, baicalein and their salts. If one or more kinds of the above compounds are used as the active component, a therapeutic agent for complement-related diseases or a health food can be prepared. The phenolic compounds have a protective effect on cells or tissues against a damage caused by a peroxidation reaction of a lipid or an enzymatic oxidation reaction in the living body and useful for prevention and therapy of collagen disease, articular rheumatism, systemic lupus erythematosus, progressive systemic sclerosis, polyarteritis nodosa, rheumatic fever dermatomyositis, allergic diseases, arterial sclerosis, hyperlipidemia, thrombosis, etc.
TAMURA NORIKO
NAKAMURA TAKESHI
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