Title:
ANTIFUNGAL AGENT AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JP3635686
Kind Code:
B2
Abstract:
PURPOSE: To obtain an antifungal agent having higher effects than a conventional antifungal agent and high safety in treatment for dermatomycosis and mycosis of viscus.
CONSTITUTION: This antifungal agent is expressed by the formula [R1 and R2 are each a halogen or H; R3 is H or a lower alkyl; (r) and (m) are 0 or 1; A is N or CH; W is an aromatic ring which may contain a hetero atom (N, S or 0) and may be replaced or its condensed ring; X is an aromatic ring which may contain a hetero atom (N, S or O) and may be replaced, an alkanediyl, an alkenediyl or alkynediyl which may be replaced, respectively; Y is S, SO2, CS, CO, O, N-R6 (R6 is H or a lower alkyl), C=N-OR6 or (CH2)1-4; Z is H, a halogen, a lower alkyl, a lower alkoxy, OH, SH, NO2, CN or phenyl, phenoxy, imidazolyl, triazolyl or amino which may be replaced, respectively] and its acid addition salt such as a compound of formula II. The compound of formula I is obtained by reacting a compound of formula III with a compound of formula IV.
Inventors:
Toshihiko Naito
Katsura
Yumiko Karai
Akihiko Tsuruoka
Takashi Tsukada
Yanagisawa Manabu
Toyozawa Itsu
Katsura
Yumiko Karai
Akihiko Tsuruoka
Takashi Tsukada
Yanagisawa Manabu
Toyozawa Itsu
Application Number:
JP20820394A
Publication Date:
April 06, 2005
Filing Date:
August 10, 1994
Export Citation:
Assignee:
EISAI CO.,LTD.
International Classes:
C07D249/08; A61K31/41; A61K31/415; A61K31/42; A61K31/425; A61K31/435; A61K31/44; A61P31/04; A61P31/10; C07B43/08; C07D403/10; C07D413/06; C07D417/06; C07D417/14; C07D513/04; (IPC1-7): C07D249/08; C07B43/08
Domestic Patent References:
| JP2104583A |
Foreign References:
| EP0321211A1 |
Other References:
James A. Ciaccio et al.,Tetrahedron Letters,英国,1992年,Vol.33, No.11,p.1431-1434