眼疾患を処置または診断する際に使用するための抗体の抗原結合フラグメント

Title:

眼疾患を処置または診断する際に使用するための抗体の抗原結合フラグメント

Document Type and Number:

Japanese Patent JP2012526075

Kind Code:

A

Abstract:

The present invention relates to the use of a fully human antigen binding fragment of an antibody for the manufacture of a medicament for the treatment or diagnosis of an ocular disease upon topical administration. The invention further relates to a pharmaceutical composition for ocular topical administration for treatment or diagnosis of an ocular disease comprising a fully human binding fragment of an antibody. In particular, the antibody neutralises HSV1 and HSV2.

Inventors:

Claire Abadi
Jean-Marc Convet
Catherine Drouche
Robert Anthony Williamson

Application Number:

JP2012509016A

Publication Date:

October 25, 2012

Filing Date:

May 04, 2010

Export Citation:

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Assignee:

REBOVACS Biotechnology Societe Anonym

International Classes:

A61K39/395; A61K9/06; A61K9/08; A61K9/107; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61P27/02; A61P31/22; C07K16/08

Domestic Patent References:

JP2007504268A	2007-03-01
JP2006517392A	2006-07-27

Foreign References:

US6156313A

2000-12-05

Other References:

JPN6014020661; ＣｏｒｎｅａＶｏｌ．２０，Ｎｏ．５, 2001, ｐ４９５-５００
JPN6014020663; Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　ＭｉｃｒｏｂｉｏｌｏｇｙＶｏｌ．３６，Ｎｏ．１１, 1998, ｐ３１９８-３２０４
JPN6014020664; Ｃｌｉｎｉｃａｌ　ａｎｄ　Ｅｘｐｅｒｉｍｅｎｔａｌ　ＩｍｍｕｎｏｌｏｇｙＶｏｌ．１２８，Ｎｏ．１, 2002, ｐ６７-７４
JPN6014020666; ＥｙｅＶｏｌ．１９，Ｎｏ．８, 2005, ｐ９１０-９１３
JPN6014020668; Ｉｎｖｅｓｔｉｇａｔｉｖｅ　Ｏｐｈｔｈａｌｍｏｌｏｇｙ　＆　Ｖｉｓｕａｌ　ＳｃｉｅｎｃｅＶｏｌ．５０，Ｎｏ．２, 200902, ｐ７７１-７７８
JPN6014020669; あたらしい眼科Ｖｏｌ．２０，Ｎｏ．３, 2003, ｐ２９７-３０２
JPN6015004006; Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡＶｏｌ．９１，Ｎｏ．１, 1994, ｐ３５５-３５９

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Takahide Sasaki

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