ANTIGEN-BINDING MOLECULES WITH INCREASED FC RECEPTOR BINDING AFFINITY AND EFFECTOR FUNCTION

Title:

ANTIGEN-BINDING MOLECULES WITH INCREASED FC RECEPTOR BINDING AFFINITY AND EFFECTOR FUNCTION

Document Type and Number:

Japanese Patent JP2015134814

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide antigen-binding molecules with increased FC receptor binding affinity and effector function.SOLUTION: The invention relates to antigen-binding molecules (ABMs). In certain embodiments, the invention relates to recombinant monoclonal antibodies including chimera, primatized, or humanized antibodies being specific for human CD20. Further, the invention relates to nucleic acid molecules encoding such ABMs as well as vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing ABMs of the invention and methods for using these ABMs in treatment of diseases. Further, the invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.

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Inventors:

UMANA PABLO
BRUENKER PETER
FERRARA CLAUDIA
SUTER TOBIAS
PUENTENER URSULA
MOESSNER EKKEHARD

Application Number:

JP2015075370A

Publication Date:

July 27, 2015

Filing Date:

April 01, 2015

Export Citation:

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Assignee:

ROCHE GLYCART AG

International Classes:

C07K16/28; A61K39/395; A61P17/02; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07H21/04; C07K16/40; C12N5/10; C12N9/10; C12N15/09; C12P21/04; C12P21/08

Domestic Patent References:

JP4653109B2

2011-03-16

Foreign References:

WO2003068821A2	2003-08-21
WO2003011878A2	2003-02-13

Other References:

JPN6009024085; Ｂｌｏｏｄ，　（２００２），　９９，　［９］，　ｐ．３２５６-３２６２
JPN6014009093; Ｂｒ．　Ｊ．　Ｃａｎｃｅｒ，　（２００１），　８４，　［８］，　ｐ．１１１５-１１２１

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Ryotaro Takei

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