ANTIGEN PROTEIN OF MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS, GENE ENCODING THE SAME PROTEIN AND METHOD FOR DIAGNOSING MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS BY USING THE SAME PROTEIN - Centro Internacional de Agricultura Tropical

Title:

ANTIGEN PROTEIN OF MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS, GENE ENCODING THE SAME PROTEIN AND METHOD FOR DIAGNOSING MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS BY USING THE SAME PROTEIN

Document Type and Number:

Japanese Patent JP3864230

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To provide an antigen protein of Mycobacterium avium subsp. paratuberculosis having IFN-γ-inducing ability and further clarify genetic information concerning the antigen protein of Mycobacterium avium subsp. paratuberculosis and readily enable mass production of the antigen protein of Mycobacterium avium subsp. paratuberculosis and to provide a method for accurately diagnosing Mycobacterium avium subsp. paratuberculosis in high sensitivity by using the antigen protein of Mycobacterium avium subsp. paratuberculosis having the IFN-γ-inducing ability.
SOLUTION: The present invention relates an antigen protein of Mycobacterium avium subsp. paratuberculosis composed of a specific amino acid sequence, a gene encoding the antigen protein of Mycobacterium avium subsp. paratuberculosis composed of a specific amino acid sequence, a cell in which the gene is induced so as to enable expression and a method for diagnosing Johne's disease comprising adding the protein or the cell to the cell of an animal to be examined, culturing the cell and detecting an interferon γ concentration in a culture supernatant.

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Inventors:

Yasuyuki Mori
Reiko Nagata
Kazuhiro Yoshihara
Yoshihiro Soda
Yuichi Yokomizo

Application Number:

JP2003334977A

Publication Date:

December 27, 2006

Filing Date:

September 26, 2003

Export Citation:

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Assignee:

Centro Internacional de Agricultura Tropical

International Classes:

C12N15/09; G01N33/53; C07K14/35; C12N1/15; C12N1/19; C12N1/21; C12N5/10; (IPC1-7): C12N15/09; C07K14/35; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/53

Domestic Patent References:

JP8056698A
JP2004065244A

Other References:

Infect Immun,2000年 2月,68(2),801-808
動物衛生試験研究成績・計画概要集平成14年度,2003年,353-354
Infect Immun,1997年 2月,65(2),387-394

Attorney, Agent or Firm:

Yuya Yano

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