Title:
cPLA2に対するアンチセンスオリゴヌクレオチド、その組成物及び使用
Document Type and Number:
Japanese Patent JP2007533318
Kind Code:
A
Abstract:
Antisense oligonucleotides against cPLA2 are provided, which are capable of inhibiting cPLA2 expression as well as superoxide production, especially in phagocytes. These antisense oligonucleotides are powerful agents for the treatment of inflammatory conditions, in particular arthritis, as well as in neurodegenerative diseases. The antisense oligonucleotides or compositions comprising the same may be used in methods of treatment of such diseases.
Inventors:
Levi, Rachel
Application Number:
JP2007509055A
Publication Date:
November 22, 2007
Filing Date:
April 17, 2005
Export Citation:
Assignee:
Mole Research Applications Limited
Ben-Gurion University of the Negev Research and Development Authority
Ben-Gurion University of the Negev Research and Development Authority
International Classes:
C12N15/09; A61K31/713; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P39/00; A61P43/00; C12N15/113; C12N
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Masakazu Noda