Title:
抗腫瘍1,2-ジフェニルピロール化合物及びその調製方法
Document Type and Number:
Japanese Patent JP2013500310
Kind Code:
A
Abstract:
The present invention relates to a new series of 1,2-diphenylpyrroles of formula (I) or their pharmaceutically acceptable salts, or th pharmaceutically acceptable solvates, having antitumor activity, wherein R 1 and R 2 are individually selected from the group consisting of halogen, optionally substituted O(C 1 -C 4 )alkyl and optionally substituted (C 1 -C 4 )alkyl; and R 3 is selected from the group consisting of H, (C 1 -C 4 )alkyl, CONH 2 and (C=NH)NH 2 . It also relates to a process for preparing them, to pharmaceutical compositions containing them, and to their use for the treatment of cancer, in particular lung carcinoma, colorectal carcinoma, breast carcinoma and/or prostate carcinoma.
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Inventors:
Manguez Bafarui, Ramon
Casanova Regalt, Isolda
Albericio Palomera, Fernando
Alvarez, mercedes
Savina, Svetlana
Casanova Regalt, Isolda
Albericio Palomera, Fernando
Alvarez, mercedes
Savina, Svetlana
Application Number:
JP2012522167A
Publication Date:
January 07, 2013
Filing Date:
July 28, 2010
Export Citation:
Assignee:
Argon Pharma, Ese. Ele.
International Classes:
C07D207/33; A61K31/402; A61P35/00; C07B61/00
Domestic Patent References:
| JPH11246403A | 1999-09-14 | |||
| JPH09323971A | 1997-12-16 |
Other References:
JPN5012014715; ＶＡＣＨＡＬ ＰＥＴＲ: 'ＧＥＮＥＲＡＬ ＦＡＣＩＬＥ ＳＹＮＴＨＥＳＩＳ ＯＦ ２，５-ＤＩＡＲＹＬＨＥＴＥＲＯＰＥＮＴＡＬＥＮＥＳ' ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ４５ Ｎ３８, 20040913, Ｐ７１５７-７１６１
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori