To produce the subject new substances comprising antitumor substances BE-66408s produced by a microorganism belonging to the genus Actinoplanes, capable of manifesting strong proliferation suppressing effects on murine and human tumorous cells and useful as a therapeutic agent, or the like, for cancers.
The new antitumor substances BE-66408s are represented by the formula (R1 and R2 are each acetoxy or H) and capable of manifesting strong proliferation suppressing effects on murine and human tumorous cells and thereby useful as a therapeutic agent, or the like, for cancers in the medicinal field. The new compounds are produced by culturing a microorganism belonging to the genus Actinoplanes and having the ability to produce the compounds represented by the formula [e.g. Actinoplanes sp. A66408 (FERM P-16539)] or its variant and collecting the resultant product from the cultured product.
TEJIMA YOSHIHIRO
NAKAJIMA SHIGERU
HIRAYAMA MIOKO
YOSHINARI TOMOKO
OJIRI KATSUHISA
SUDA HIROYUKI
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