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Title:
ANTIULCER AGENT
Document Type and Number:
Japanese Patent JPS62209019
Kind Code:
A
Abstract:

PURPOSE: To provide an antiulcer agent exhibiting excellent drug action especially against stress ulcers, by using a specific compound known as a cyanine- type photosensitive dye and remedy for frostbite and scald as an active component.

CONSTITUTION: A compound of formula (R is H or 1W4C alkyl; X is halogen) is used as an antiulcer agent. A concrete example of the compound is 4,4'-{3-{2-[1-ethyl-4-( 1-H )quinolidene]ethylidene}}propenylene[bis(1-ethylquinoli nium iodide)]. It is administered preferably by oral administration at a dose of preferably 80W200μg/kg. The compound of formula exhibits high drug action as a remedy for central ulcer. The compound can be produced by reacting aniline with methyl vinyl ketone to obtain lepidine, separately preparing a diformyl derivative of the compound of formula by Vilsmeier reaction, reacting the derivative with the above-obtained lepidine and reacting the reaction product with desired alkyl halide.


Inventors:
OKIMURA TSUTOMU
SASAKI YASUO
Application Number:
JP5123186A
Publication Date:
September 14, 1987
Filing Date:
March 08, 1986
Export Citation:
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Assignee:
MORISHITA JINTAN CO
International Classes:
C07D215/10; A61K31/47; A61P1/04; (IPC1-7): A61K31/47; C07D215/10
Attorney, Agent or Firm:
Aoyama



 
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