Title:
ANTIVIRAL COMBINATION
Document Type and Number:
Japanese Patent JP2868671
Kind Code:
B2
Abstract:
PURPOSE: To provide a prescribed agent which consists of a combination of a specific 1,3-oxathiolanenucleoside analogue and another HIV replication inhibitor and has a synergistic viral effect and reduced cytotoxicity.
CONSTITUTION: This prescribed agent consists of a composition contg. a compound represented by the formula or its pharmaceutically-acceptable derivative (preferably, (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolane-5-yl)-1H- pyrimidine-2-one that is a (-) enantiomer, or its salt) and an HIV replication inhibitor (preferably, 3'-azido-3'-deoxythymidine or 2',3'-dioxyinosine), together with a pharmaceutically-acceptable carrier for them. The enantiomer of the compound represented by the formula has remarkably lower cytotoxicity as compared with the (+) enantiomer and such a compound consists essentially of the (-) enantiomer and contains substantially no (+) enantiomer (≤1 wt.%) is preferably used.
Inventors:
JANETSUTO MEARII KAMERON
NIKORASU KAMATSUKU
NIKORASU KAMATSUKU
Application Number:
JP14838492A
Publication Date:
March 10, 1999
Filing Date:
May 15, 1992
Export Citation:
Assignee:
GURAKUSO GURUUPU LTD
International Classes:
A61K31/47; A61K31/39; A61K31/415; A61K31/505; A61K31/55; A61K31/655; A61K31/70; A61K31/7068; A61K45/00; A61K45/06; A61P31/12; A61P35/00; A61P37/04; A61P43/00; C07D239/00; C07D411/04; A61K31/7072; A61K; (IPC1-7): A61K31/505; A61K31/505
Domestic Patent References:
| JP5501117A | ||||
| JP6506199A | ||||
| JP37282A | ||||
| JP2204414A | ||||
| JP2142733A | ||||
| JP6438030A | ||||
| JP2270876A | ||||
| JP2504283A |
Other References:
【文献】国際公開90/8550(WO,A1)
【文献】国際公開90/11081(WO,A1)
【文献】国際公開90/14830(WO,A1)
【文献】国際公開90/11081(WO,A1)
【文献】国際公開90/14830(WO,A1)
Attorney, Agent or Firm:
Kazuo Sato (2 outside)