APPARATUS AND METHOD FOR CREATING AND TESTING PRE-FORMULATION, AND SYSTEM THEREFOR

Japanese Patent JP2008224686

A

To provide a methods, an apparatus, and a system for performing a high-throughput preparation and a screening of salts and polymorphs of drug candidates.

The method is directed toward enhancing the pre-formulation discovery process used for a drug development. In particular, processes of determining suitable salts and processes of discovering substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members from, for example, a library model generated by a computer system.

CARLSON ERIC D
CONG PEIJUN
CHANDLER WILLIAM H JR
CHAU HENRY K
DANIELSON EARL
DESROSIERS PETER J
DOOLAN ROBERT D
WU LUPING

JP2008140198A

September 25, 2008

May 28, 2008

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SYMYX TECHNOLOGIES INC

G01N21/64; G01N33/50; B01J19/00; B01L3/00; C07D209/20; C07D293/00; C40B60/08; G01N21/23; G01N21/27; G01N21/33; G01N21/35; G01N21/47; G01N21/65; G01N21/78; G01N24/08; G01N25/04; G01N30/88; G01N33/15; G01N33/483; G01N33/53; G01N33/543; G01N35/02; G01N37/00; B01L3/06; B01L7/00; C07B61/00; C40B40/10; C40B60/14; G01N5/04; G01N13/00

JP2003519698A	2003-06-24
JP2003504641A	2003-02-04
JP2002543955A	2002-12-24
JP2003500205A	2003-01-07

WO2001051919A2	2001-07-19
WO2001006250A2	2001-01-25
WO2000067872A2	2000-11-16
WO2000072968A1	2000-12-07

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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